NF 449
Modify Date: 2024-01-12 20:01:51
NF 449 structure
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Common Name | NF 449 | ||
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| CAS Number | 627034-85-9 | Molecular Weight | 1505.090 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C41H24N6Na8O29S8 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NF 449NF449 octasodium is a highly potent P2X1 receptor antagonist, with IC50s of 0.28, 0.69, and 120 nM for rP2X1, rP2X1+5, P2X2+3, respectively. NF449 octasodium is a Gsα-selective G Protein antagonist. NF449 octasodium suppresses the rate of GTP[γS] binding to Gsα-s, inhibits the stimulation of adenylyl cyclase activity, and blocks the coupling of β-adrenergic receptors to Gs[1][2]. |
| Name | nf449 |
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| Synonym | More Synonyms |
| Description | NF449 octasodium is a highly potent P2X1 receptor antagonist, with IC50s of 0.28, 0.69, and 120 nM for rP2X1, rP2X1+5, P2X2+3, respectively. NF449 octasodium is a Gsα-selective G Protein antagonist. NF449 octasodium suppresses the rate of GTP[γS] binding to Gsα-s, inhibits the stimulation of adenylyl cyclase activity, and blocks the coupling of β-adrenergic receptors to Gs[1][2]. |
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| Related Catalog | |
| In Vitro | NF449 suppressed the rate of GTP[γS] binding to rGsα-s while barely affecting binding to rGiα-1 (IC50=140 nM), inhibits stimulation of adenylyl cyclase activity in S49 cyc− membranes (deficient in endogenous Gsα) by exogenously added Gsα-s, and blocks the coupling of β-adrenergic receptors to Gs (EC50=7.9 μM)[2]. |
| In Vivo | At a dose of 10 mg/kg, NF449 inhibits the ex vivo aggregation triggered by 5 g/ml collagen in WT mouse platelets without affecting that induced by 5 μM ADP. At a higher dose (50 mg/kg), NF449 inhibits ex vivo platelet aggregation in response to not only 10 g/ml collagen but also 5 M ADP, indicating nonselective inhibition of the P2Y1 and/or P2Y12 receptor[3]. |
| References |
| Molecular Formula | C41H24N6Na8O29S8 |
|---|---|
| Molecular Weight | 1505.090 |
| Exact Mass | 1503.753540 |
| PSA | 682.17000 |
| LogP | 8.65700 |
| 1,3-Benzenedisulfonic acid, 4,4',4'',4'''-[carbonylbis[iminobenzene-5,1,3-triylbis(carbonylimino)]]tetrakis-, sodium salt (1:8) |
| Octasodium 4,4',4'',4'''-{carbonylbis[iminobenzene-5,1,3-triylbis(carbonylimino)]}tetra(1,3-benzenedisulfonate) |
| Octasodium 4-({3-[({3,5-bis[(2,4-disulfonatophenyl)carbamoyl]phenyl}carbamoyl)amino]-5-[(2,4-disulfonatophenyl)carbamoyl]benzoyl}amino)benzene-1,3-disulfonate |