Cytidine

Modify Date: 2024-01-02 14:21:41

Cytidine structure	Common Name	Cytidine
	CAS Number	65-46-3	Molecular Weight	243.217
	Density	1.9±0.1 g/cm3	Boiling Point	529.7±60.0 °C at 760 mmHg
	Molecular Formula	C₉H₁₃N₃O₅	Melting Point	210-220 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	274.1±32.9 °C

Use of Cytidine

Cytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring, cytidine is a component of RNA.Target: Nucleoside antimetabolite/analogCytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring (also known as a ribofuranose) via a β-N1-glycosidic bond. Cytidine is a component of RNA. If cytosine is attached to a deoxyribose ring, it is known as a deoxycytidine. Dietary sources of cytidine include foods with high RNA (ribonucleic acid) content, such as organ meats, Brewer's yeast, as well as pyrimidine-rich foods such as beer. During digestion, RNA-rich foods are broken-down into ribosyl pyrimidines (cytidine and uridine), which are absorbed intact. In humans, dietary cytidine is converted into uridine, which is probably the compound behind cytidine's metabolic effects.There are a variety of cytidine analogs with potentially useful pharmacology. For example, KP-1461 is an anti-HIV agent that works as a viral mutagen, and zebularine exists in E. coli and is being examined for chemotherapy. Low doses of azacitidine and its analog decitabine have shown results against cancer through epigenetic demethylation.

Name	Cytidine
Synonym	More Synonyms

Description	Cytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring, cytidine is a component of RNA.Target: Nucleoside antimetabolite/analogCytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring (also known as a ribofuranose) via a β-N1-glycosidic bond. Cytidine is a component of RNA. If cytosine is attached to a deoxyribose ring, it is known as a deoxycytidine. Dietary sources of cytidine include foods with high RNA (ribonucleic acid) content, such as organ meats, Brewer's yeast, as well as pyrimidine-rich foods such as beer. During digestion, RNA-rich foods are broken-down into ribosyl pyrimidines (cytidine and uridine), which are absorbed intact. In humans, dietary cytidine is converted into uridine, which is probably the compound behind cytidine's metabolic effects.There are a variety of cytidine analogs with potentially useful pharmacology. For example, KP-1461 is an anti-HIV agent that works as a viral mutagen, and zebularine exists in E. coli and is being examined for chemotherapy. Low doses of azacitidine and its analog decitabine have shown results against cancer through epigenetic demethylation.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Natural Products >> Alkaloid Research Areas >> Cancer
Target	Human Endogenous Metabolite
References	[1]. Jonas DA, et al. Safety considerations of DNA in food. Ann Nutr Metab. 2001;45(6):235-54. [2]. Wurtman RJ, et al. Effect of oral CDP-choline on plasma choline and uridine levels in humans. Biochem Pharmacol. 2000 Oct 1;60(7):989-92.

Density	1.9±0.1 g/cm3
Boiling Point	529.7±60.0 °C at 760 mmHg
Melting Point	210-220 °C (dec.)(lit.)
Molecular Formula	C₉H₁₃N₃O₅
Molecular Weight	243.217
Flash Point	274.1±32.9 °C
Exact Mass	243.085526
PSA	130.83000
LogP	-1.78
Vapour Pressure	0.0±3.2 mmHg at 25°C
Index of Refraction	1.756
Water Solubility	SOLUBLE

Cytidine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UW7370000

CHEMICAL NAME :: 2(1H)-Pyrimidinone, 4-amino-1-beta-D-ribofuranosyl-

CAS REGISTRY NUMBER :: 65-46-3

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C9-H13-N3-O5

MOLECULAR WEIGHT :: 243.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2700 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 150 umol/L

REFERENCE :: PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 48,686,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9990 No. of Facilities: 35 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 115 (estimated) No. of Female Employees: 64 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	F+
Risk Phrases	R68
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UW7370000
HS Code	2934999090

Precursor 7
CAS#:56787-28-1 2',3',5'-TRI-O-... CAS#:5040-18-6 N-Acetyl-2'-O,3... CAS#:800379-05-9 N4-(O-(benzylox... CAS#:3530-56-1 xylocytidine
CAS#:23624-64-8 Cytidine, N-ben... CAS#:58-96-8 Uridine CAS#:362-42-5 Cytidine,2',3'-...
DownStream 10
CAS#:3066-86-2 5-Bromocytidine CAS#:3768-18-1 N-Acetylcytidine CAS#:31698-14-3 Ancitabine CAS#:50-69-1 D-Ribose
CAS#:71-30-7 cytosine CAS#:36791-04-5 Ribavirin CAS#:4105-38-8 uridine triacetate CAS#:2140-64-9 3-Methylcytidine
CAS#:20594-00-7 3'-(O-METHYL)CY... CAS#:2140-72-9 2′-O-methylcytidine

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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1-(b-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine

EINECS 200-610-9

4-Amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-2(1H)-pyrimidinone

2(1H)-Pyrimidinone, 4-amino-1-β-D-ribofuranosyl-

1-β-D-Ribofuranosylcytosine

4-Amino-1-β-δ-ribofuranosyl-2(1H)-pyrimidinone

4-Amino-1-(β-D-ribofuranosyl)pyrimidin-2(1H)-on

MFCD02181091

Cytidine

4-Amino-1-b-D-ribofuranosyl-2(1H)-pyrimidinone

Cyd

Cytidin

1-β-D-ribofuranosyl-Cytosine

Citidine

1-(b-δ-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine

Cytosine, 1-β-D-ribofuranosyl-

d-cytidine

1-β-δ-Ribofuranosylcytosine

CYTIDINE extrapure

1-b-D-Ribofuranosylcytosine

2-Pyrimidinol, 1,4-dihydro-4-imino-1-β-D-ribofuranosyl-

4-Imino-1-(β-D-ribofuranosyl)-1,4-dihydro-2-pyrimidinol

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Cytidine

Use of Cytidine

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Cytidine Biological Activity

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CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

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