penconazole

Modify Date: 2024-01-03 11:22:54

penconazole Structure
penconazole structure
Common Name penconazole
CAS Number 66246-88-6 Molecular Weight 284.184
Density 1.3±0.1 g/cm3 Boiling Point 415.3±55.0 °C at 760 mmHg
Molecular Formula C13H15Cl2N3 Melting Point 57.6-60.3ºC
MSDS Chinese USA Flash Point 204.9±31.5 °C
Symbol GHS07 GHS08 GHS09
GHS07, GHS08, GHS09
Signal Word Warning

 Use of penconazole


Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats[1][2].

 Names

Name penconazole
Synonym More Synonyms

 penconazole Biological Activity

Description Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats[1][2].
Related Catalog
In Vivo Penconazole (67 mg/kg; i.p.; every 2 days during 9 days) induces oxidative stress in rat cerebrum and cerebellum tissues[2]. Penconazole has the ability to induce oxidative damage in the brain of adult rats, as evidenced by an increase of lipid peroxidation and protein oxidation, in addition to the perturbations in the enzymatic and nonenzymatic antioxidant status. Penconazole also affects the cholinergic system, activities of membrane-bound ATPases, and brain histoarchitecture. Penconazole is a potential neurotoxicant pesticide that exerts its neurotoxic effects via the generation of oxidative stress. Penconazole causes a significant inhibition of AChE activity in the cerebrum (11%) and cerebellum (25%) of adult rats[2]. Animal Model: Twelve male Wistar rats[2] Dosage: 67 mg/kg Administration: I.p.; every 2 days during 9 days Result: A significant increase was obtained in the absolute and relative weights of the cerebrum and cerebellum, respectively.
References

[1]. Husak VV, et al. Acute exposure to the penconazole-containing fungicide Topas partially augments antioxidant potential in goldfish tissues. Comp Biochem Physiol C Toxicol Pharmacol. 2017;193:1-8.

[2]. Chaâbane M, et al. Penconazole alters redox status, cholinergic function, and membrane-bound ATPases in the cerebrum and cerebellum of adult rats. Hum Exp Toxicol. 2017;36(8):854-866.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 415.3±55.0 °C at 760 mmHg
Melting Point 57.6-60.3ºC
Molecular Formula C13H15Cl2N3
Molecular Weight 284.184
Flash Point 204.9±31.5 °C
Exact Mass 283.064301
PSA 30.71000
LogP 3.66
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.602
Storage condition 0-6°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XZ4615000
CHEMICAL NAME :
1H-1,2,4-Triazole, 1-(2-(2,4-dichlorophenyl)pentyl)-
CAS REGISTRY NUMBER :
66246-88-6
BEILSTEIN REFERENCE NO. :
0541488
LAST UPDATED :
199710
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C13-H15-Cl2-N3
MOLECULAR WEIGHT :
284.21

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2125 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,554,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 38,195,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2444 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 38,195,1984

 Safety Information

Symbol GHS07 GHS08 GHS09
GHS07, GHS08, GHS09
Signal Word Warning
Hazard Statements H302-H361d-H410
Precautionary Statements P201-P273-P301 + P312 + P330-P308 + P313-P391-P501
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Safety Phrases S22-S24/25
RIDADR UN 3077 9 / PGIII
RTECS XZ4615000
HS Code 2933990015

 Synthetic Route

~%

penconazole Structure

penconazole

CAS#:66246-88-6

Literature: US4556717 A1, ;

 Precursor & DownStream

Precursor  1

DownStream  0

 Customs

HS Code 2933990016
Summary 2933990016 1-(2-(2,4-dichlorophenyl)pentyl)-1h-1,2,4-triazole。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

 Articles24

More Articles
The dissipation of three fungicides in a biobed organic substrate and their impact on the structure and activity of the microbial community.

Environ. Sci. Pollut. Res. Int. 20(4) , 2546-55, (2013)

Biopurification systems (BPS) have been introduced to minimise the risk for point source contamination of natural water resources by pesticides. Their depuration efficiency relies mostly on the high b...

Enantiomeric separation of triazole fungicides with 3-μm and 5-μml particle chiral columns by reverse-phase high-performance liquid chromatography.

Chirality 23(6) , 479-86, (2011)

This study used chiral columns packed with 3-μm and 5-μm particles to comparatively separate enantiomers of 9 triazole fungicides, and Lux Cellulose-1 columns with chiral stationary phase of cellulose...

Biological monitoring of pesticide exposures in residents living near agricultural land.

BMC Public Health 11 , 856, (2011)

There is currently a lack of reliable information on the exposures of residents and bystanders to pesticides in the UK. Previous research has shown that the methods currently used for assessing pestic...

 Synonyms

topasmz
(RS)-1-[2-(2,4-dichlorophenyl)pentyl]-1H-1,2,4-triazole
EINECS 266-275-6
PENCONAZOL
T5NN DNJ A1Y3&R BG DG
1-[2-(2,4-Dichlorophenyl)pentyl]-1H-1,2,4-triazole
onmex
MFCD00078737
1-[2-(2,4-Dichlorophenyl)-n-pentyl]-1H-1,2,4-triazole
Topas
1-(2,4-Dichloro-β-propylphenethyl)-1H-1,2,4-triazole
topaze
1H-1,2,4-Triazole, 1-[2-(2,4-dichlorophenyl)pentyl]-
topazec
penconazole
topasc
Pine gel
rac-1-[(2R)-2-(2,4-dichlorophenyl)pentyl]-1H-1,2,4-triazole
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