Terconazole
Terconazole structure
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Common Name | Terconazole | ||
|---|---|---|---|---|
| CAS Number | 67915-31-5 | Molecular Weight | 532.46200 | |
| Density | 1.35g/cm3 | Boiling Point | 681.8ºC at 760mmHg | |
| Molecular Formula | C26H31Cl2N5O3 | Melting Point | 126.3ºC | |
| MSDS | Chinese USA | Flash Point | 366.2ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of TerconazoleTerconazole is a broad-spectrum antifungal medication for the treatment of vaginal yeast infection. |
| Name | Terconazole |
|---|---|
| Synonym | More Synonyms |
| Description | Terconazole is a broad-spectrum antifungal medication for the treatment of vaginal yeast infection. |
|---|---|
| Related Catalog | |
| In Vitro | Terconazole inhibits the growth of Candida albicans ATCC 44859 in a concentration-related manner, but with modest effects noted at levels from 0.1 to 10 μM when the yeast is grown on media favoring the cell form. The inhibitory potency of terconazole on yeast cell viability varies with the strain and species of Candida tested. The susceptibility of C. albicans ATCC 44859 to terconazole is markedly enhanced when the yeast is grown on Eagle minimum essential medium, which favors mycelium formation. There is a progression of changes, from loss of mycelia formation at 0.1 μM terconazole through complete necrosis at 100 μM[1]. Terconazole blocks the morphogenetic transformation from the yeast into the filamentous form at concentrations of 0.008 to 0.05 microgram/mL[2]. |
| In Vivo | A 3-day once-daily intravaginal application of terconazole 0.8% is usually sufficient to provide a functional therapeutic period of 7 days because of prolonged high biologically active antifungal levels in the vagina. No side effects are observed at any concentration of terconazole[2]. |
| Animal Admin | Rats: The rats are infected intravaginally with C. albicans. They are treated topically twice daily for 3 days, starting 24 hours after infection with a volume of 0.2 mL of various concentrations of terconazole (0.125%, 0.25%, 0.4%, 0.5%, 1%, 2%), miconazole, clotrimazole, econazole, nystatin, or amphotericin B[2]. |
| References |
| Density | 1.35g/cm3 |
|---|---|
| Boiling Point | 681.8ºC at 760mmHg |
| Melting Point | 126.3ºC |
| Molecular Formula | C26H31Cl2N5O3 |
| Molecular Weight | 532.46200 |
| Flash Point | 366.2ºC |
| Exact Mass | 531.18000 |
| PSA | 64.88000 |
| LogP | 4.46560 |
| Index of Refraction | 1.64 |
| Storage condition | 2-8°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335-H413 |
| Precautionary Statements | P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Phrases | 36/37/38-53 |
| Safety Phrases | 26 |
| RIDADR | NONH for all modes of transport |
| RTECS | TL3564600 |
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~%
Terconazole CAS#:67915-31-5 |
| Literature: Journal of Medicinal Chemistry, , vol. 26, # 4 p. 611 - 613 |
|
~%
Terconazole CAS#:67915-31-5 |
| Literature: Journal of Medicinal Chemistry, , vol. 26, # 4 p. 611 - 613 |
|
~%
Terconazole CAS#:67915-31-5 |
| Literature: Journal of Medicinal Chemistry, , vol. 26, # 4 p. 611 - 613 |
|
~%
Terconazole CAS#:67915-31-5 |
| Literature: Journal of Medicinal Chemistry, , vol. 26, # 4 p. 611 - 613 |
|
~%
Terconazole CAS#:67915-31-5 |
| Literature: Journal of Medicinal Chemistry, , vol. 26, # 4 p. 611 - 613 |
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Azole antifungal inhibition of buprenorphine, methadone and oxycodone in vitro metabolism.
J. Anal. Toxicol. 39 , 374-86, (2015) Opioid-related mortality rates have escalated. Drug interactions may increase blood concentrations of the opioid. We therefore used human liver microsomes (HLMs) and cDNA-expressed human cytochrome P4... |
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High sensitive multiresidue analysis of pharmaceuticals and antifungals in surface water using U-HPLC-Q-Exactive Orbitrap HRMS. Application to the Danube river basin on the Romanian territory.
Sci. Total Environ. 532 , 501-11, (2015) The occurrence of 67 pharmaceutical and antifungal residues in the Danube river on the Romanian territory was studied by using solid-phase extraction (SPE) and LC-Q Exactive Orbitrap high resolution M... |
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Resistance status of the Colorado potato beetle, Leptinotarsa decemlineata, to endosulfan in East Azarbaijan and Ardabil provinces of Iran.
J. Insect Sci. 7 , 1-7, (2007) Three Colorado potato beetle, Leptinotarsa decemlineata, populations, from Ardabil, Bostanabaad and Ajabshir, were collected from potato fields in East Azarbaijan and Ardabil provinces in Iran and ass... |
| Terconagole |
| MFCD05662369 |
| Fungistat |
| EINECS 267-751-6 |
| Triaconazole |
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