Top Suppliers:I want be here
Related CAS#:
67915-31-5 220243-81-2
1486497-66-8 1158522-08-7
940364-43-2 134104-43-1
131615-57-1 6906-52-1
930439-75-1 1018584-77-4
1375289-11-4 849349-65-1
127437-46-1

67915-31-5

67915-31-5 structure
67915-31-5 structure
Name Terconazole
Synonyms Terconagole
MFCD05662369
Fungistat
EINECS 267-751-6
Triaconazole
Description Terconazole is a broad-spectrum antifungal medication for the treatment of vaginal yeast infection.
Related Catalog
In Vitro Terconazole inhibits the growth of Candida albicans ATCC 44859 in a concentration-related manner, but with modest effects noted at levels from 0.1 to 10 μM when the yeast is grown on media favoring the cell form. The inhibitory potency of terconazole on yeast cell viability varies with the strain and species of Candida tested. The susceptibility of C. albicans ATCC 44859 to terconazole is markedly enhanced when the yeast is grown on Eagle minimum essential medium, which favors mycelium formation. There is a progression of changes, from loss of mycelia formation at 0.1 μM terconazole through complete necrosis at 100 μM[1]. Terconazole blocks the morphogenetic transformation from the yeast into the filamentous form at concentrations of 0.008 to 0.05 microgram/mL[2].
In Vivo A 3-day once-daily intravaginal application of terconazole 0.8% is usually sufficient to provide a functional therapeutic period of 7 days because of prolonged high biologically active antifungal levels in the vagina. No side effects are observed at any concentration of terconazole[2].
Animal Admin Rats: The rats are infected intravaginally with C. albicans. They are treated topically twice daily for 3 days, starting 24 hours after infection with a volume of 0.2 mL of various concentrations of terconazole (0.125%, 0.25%, 0.4%, 0.5%, 1%, 2%), miconazole, clotrimazole, econazole, nystatin, or amphotericin B[2].
References

[1]. Tolman EL, et al. Anticandidal activities of terconazole, a broad-spectrum antimycotic. Antimicrob Agents Chemother. 1986 Jun;29(6):986-91.

[2]. Van Cutsem J, et al. The in vitro activity of terconazole against yeasts: its topical long-acting therapeutic efficacy in experimental vaginal candidiasis in rats. Am J Obstet Gynecol. 1991 Oct;165(4 Pt 2):1200-6.
Density 1.35g/cm3
Boiling Point 681.8ºC at 760mmHg
Melting Point 126.3ºC
Molecular Formula C26H31Cl2N5O3
Molecular Weight 532.46200
Flash Point 366.2ºC
Exact Mass 531.18000
PSA 64.88000
LogP 4.46560
Index of Refraction 1.64
Storage condition 2-8°C
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335-H413
Precautionary Statements P305 + P351 + P338
Hazard Codes Xi
Risk Phrases 36/37/38-53
Safety Phrases 26
RIDADR NONH for all modes of transport
RTECS TL3564600

Chemsrc provides CAS#:67915-31-5 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 67915-31-5 | Chemsrc address: https://www.chemsrc.com/en/baike/335808.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved