BRL 44408 maleate

Modify Date: 2024-01-20 07:38:20

BRL 44408 maleate Structure
BRL 44408 maleate structure
Common Name BRL 44408 maleate
CAS Number 681806-46-2 Molecular Weight 331.36600
Density N/A Boiling Point N/A
Molecular Formula C17H21N3O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BRL 44408 maleate


BRL-44408 maleate is an α2A-adrenoceptor antagonist (Ki: 8.5 nM). BRL-44408 maleate has antidepressant and analgesic activity. BRL-44408 also improves cecal ligation puncture (CLP)-induced acute lung injury[1][2].

 Names

Name BRL-44408 maleate
Synonym More Synonyms

 BRL 44408 maleate Biological Activity

Description BRL-44408 maleate is an α2A-adrenoceptor antagonist (Ki: 8.5 nM). BRL-44408 maleate has antidepressant and analgesic activity. BRL-44408 also improves cecal ligation puncture (CLP)-induced acute lung injury[1][2].
Related Catalog
Target

Ki: 8.5 nM (α2A-adrenoceptor)[1]

References

[1]. Dwyer JM, et al. Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective alpha2A-adrenoceptor antagonism. Int J Neuropsychopharmacol. 2010 Oct;13(9):1193-205.  

[2]. Cong Z, et al. α2A -AR antagonism by BRL-44408 maleate attenuates acute lung injury in rats with downregulation of ERK1/2, p38MAPK, and p65 pathway. J Cell Physiol. 2020 Oct;235(10):6905-6914.  

 Chemical & Physical Properties

Molecular Formula C17H21N3O4
Molecular Weight 331.36600
Exact Mass 331.15300
PSA 102.23000
LogP 0.97900

 Synonyms

BRL44408 maleate
2-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole maleate
2-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindolemaleate
2-[(2H-1-methyl-1,3-dihydroisoindole)methyl]-4,5-dihydroimidazole maleate
BRL 44408 maleate
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