ABT-724
Modify Date: 2024-01-27 00:43:59
ABT-724 structure
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Common Name | ABT-724 | ||
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| CAS Number | 70006-24-5 | Molecular Weight | 293.36600 | |
| Density | 1.275g/cm3 | Boiling Point | 548.6ºC at 760 mmHg | |
| Molecular Formula | C17H19N5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 285.6ºC | |
Use of ABT-724ABT-724 is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM). ABT-724 has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 could be useful for the treatment of erectile dysfunction and has favorable side-effect profile[1]. |
| Name | ABT 724 trihydrochloride,2-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazoletrihydrochloride |
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| Synonym | More Synonyms |
| Description | ABT-724 is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM). ABT-724 has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 could be useful for the treatment of erectile dysfunction and has favorable side-effect profile[1]. |
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| Related Catalog | |
| Target |
EC50: 12.4 nM (Human dopamine D4 receptor), 14.3 nM (Rat dopamine D4 receptor) and 23.2 nM (Ferret dopamine D4 receptor)[1] |
| In Vitro | ABT-724 exhibits a selective biochemical profile, as indicates by a lack of binding affinity for >70 neurotransmitter/uptake/ion channels including D2, D3, or D5 receptors up to a 10 μM concentration. A weak affinity to 5-HT1A receptors (Ki = 2780 nM) is observed. ABT-724 does not inhibit the PDE activity of PDE1, PDE5, or PDE6 at 10 μM concentrations[1]. |
| In Vivo | ABT-724 (8.8 μg/kg; subcutaneous injection; daily; for 5 days; male adult Wistar rats) treatment dose-dependently facilitates penile erection when given s.c. to conscious rats[1]. Animal Model: Male adult Wistar rats (~300 g)[1] Dosage: 8.8 μg/kg Administration: Subcutaneous injection; daily; for 5 days Result: Dose-dependently facilitated penile erection. |
| References |
| Density | 1.275g/cm3 |
|---|---|
| Boiling Point | 548.6ºC at 760 mmHg |
| Molecular Formula | C17H19N5 |
| Molecular Weight | 293.36600 |
| Flash Point | 285.6ºC |
| Exact Mass | 293.16400 |
| PSA | 48.05000 |
| LogP | 2.28300 |
| Index of Refraction | 1.687 |
| Hazard Codes | Xi |
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~70%
ABT-724 CAS#:70006-24-5 |
| Literature: Cowart, Marlon D.; Bhatia, Pramila A.; Daanen, Jerome F.; Stewart, Andrew O.; Patel, Meena V.; Kolasa, Teodozyj; Brioni, Jorge D.; Rohde, Jeffrey Patent: US2002/169166 A1, 2002 ; |
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~74%
ABT-724 CAS#:70006-24-5 |
| Literature: Cowart, Marlon; Latshaw, Steven P.; Bhatia, Pramila; Daanen, Jerome F.; Rohde, Jeffrey; Nelson, Sherry L.; Patel, Meena; Kolasa, Teodozyi; Nakane, Masaki; Uchic, Marie E.; Miller, Loan N.; Terranova, Marc A.; Chang, Renjie; Donnelly-Roberts, Diana L.; Namovic, Marian T.; Hollingsworth, Peter R.; Martino, Brenda R.; Lynch III, James J.; Sullivan, James P.; Hsieh, Gin C.; Moreland, Robert B.; Brioni, Jorge D.; Stewart, Andrew O. Journal of Medicinal Chemistry, 2004 , vol. 47, # 15 p. 3853 - 3864 |
| Precursor 2 | |
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| DownStream 0 | |
| abt 724 trihydrochloride |
| abt 724 |