Oxypeucedanin

Modify Date: 2024-01-02 15:10:17

Oxypeucedanin Structure
Oxypeucedanin structure
Common Name Oxypeucedanin
CAS Number 737-52-0 Molecular Weight 286.279
Density 1.4±0.1 g/cm3 Boiling Point 469.6±45.0 °C at 760 mmHg
Molecular Formula C16H14O5 Melting Point 141-142 °C
MSDS N/A Flash Point 237.8±28.7 °C

 Use of Oxypeucedanin


Oxypeucedanin is a furocoumarin derivative isolated from Angelica dahurica. Oxypeucedanin is a selective open-channel blocker, inhibits the hKv1.5 current with an IC50 value of 76 nM. Oxypeucedanin prolongs cardiac action potential duration (APD), is a potential antiarrhythmic agent for atrial fibrillation[1]. Oxypeucedanin induces cell apoptosis through inhibition of cancer cell migration[2].

 Names

Name oxypeucedanin
Synonym More Synonyms

 Oxypeucedanin Biological Activity

Description Oxypeucedanin is a furocoumarin derivative isolated from Angelica dahurica. Oxypeucedanin is a selective open-channel blocker, inhibits the hKv1.5 current with an IC50 value of 76 nM. Oxypeucedanin prolongs cardiac action potential duration (APD), is a potential antiarrhythmic agent for atrial fibrillation[1]. Oxypeucedanin induces cell apoptosis through inhibition of cancer cell migration[2].
Related Catalog
Target

IC50: HKv1.5 current; apoptosis[1]

References

[1]. Eun JS, et al. Effects of oxypeucedanin on hKv1.5 and action potential duration.Biol Pharm Bull. 2005 Apr;28(4):657-60.

[2]. Yu Liu, et al. Oxypeucedanin hydrate monoacetate isolated from Angelica dahurica induces apoptosis in Caco-2 colon carcinoma cells through the mediation of PI3K-signalling pathway and inhibition of cancer cell migration

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 469.6±45.0 °C at 760 mmHg
Melting Point 141-142 °C
Molecular Formula C16H14O5
Molecular Weight 286.279
Flash Point 237.8±28.7 °C
Exact Mass 286.084137
PSA 65.11000
LogP 2.17
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.634
Storage condition 2-8°C

 Safety Information

Hazard Codes Xi

 Synthetic Route

~86%

Oxypeucedanin Structure

Oxypeucedanin

CAS#:737-52-0

Literature: Row; Brown; Stachulski; Lennard Organic and Biomolecular Chemistry, 2006 , vol. 4, # 8 p. 1604 - 1610

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Oxypeucedanin Structure

Oxypeucedanin

CAS#:737-52-0

Literature: Organic and Biomolecular Chemistry, , vol. 4, # 8 p. 1604 - 1610

~%

Oxypeucedanin Structure

Oxypeucedanin

CAS#:737-52-0

Literature: Organic and Biomolecular Chemistry, , vol. 4, # 8 p. 1604 - 1610

~%

Oxypeucedanin Structure

Oxypeucedanin

CAS#:737-52-0

Literature: Organic and Biomolecular Chemistry, , vol. 4, # 8 p. 1604 - 1610

 Synonyms

4-(3,3-Dimethyl-oxiranylmethoxy)-furo[3,2-g]chromen-7-one
7H-Furo(3,2-g)(1)benzopyran-7-one, 4-((3,3-dimethyloxiranyl)methoxy)-
5-[(3,3-Dimethyl-2-oxiranyl)methoxy]-7H-furo[3,2-g]chromen-7-one
4-[(3,3-Dimethyl-2-oxiranyl)methoxy]-7H-furo[3,2-g]chromen-7-one
7H-Furo[3,2-g][1]benzopyran-7-one, 5-[(3,3-dimethyloxiranyl)methoxy]-
7H-Furo[3,2-g][1]benzopyran-7-one, 4-[(3,3-dimethyloxiranyl)methoxy]-
Oxypencedanin
5-[(3,3-Dimethyloxiran-2-yl)methoxy]-7H-furo[3,2-g]chromen-7-one
oxypeucadanin
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