5-Geranoxy-7-methoxycoumarin

Modify Date: 2024-01-03 22:13:40

5-Geranoxy-7-methoxycoumarin Structure
5-Geranoxy-7-methoxycoumarin structure
Common Name 5-Geranoxy-7-methoxycoumarin
CAS Number 7380-39-4 Molecular Weight 328.40
Density 1.092g/cm3 Boiling Point 487.1ºC at 760 mmHg
Molecular Formula C20H24O4 Melting Point 86-88ºC
MSDS N/A Flash Point 213.2ºC

 Use of 5-Geranoxy-7-methoxycoumarin


5-Geranoxy-7-methoxycoumarin is a coumarin with anti-cancer, antifungal, and  antibacterial activities. 5-Geranoxy-7-methoxycoumarin induces cell apoptosis[1][2].

 Names

Name 5-[(2E)-3,7-dimethylocta-2,6-dienoxy]-7-methoxychromen-2-one
Synonym More Synonyms

 5-Geranoxy-7-methoxycoumarin Biological Activity

Description 5-Geranoxy-7-methoxycoumarin is a coumarin with anti-cancer, antifungal, and  antibacterial activities. 5-Geranoxy-7-methoxycoumarin induces cell apoptosis[1][2].
Related Catalog
In Vitro 5-Geranoxy-7-methoxycoumarin (12.5-200 µM; 24-72 hours) induces a significant inhibition of cell growth in a time-dependent manner in SW480 cells[1]. 5-Geranoxy-7-methoxycoumarin (50 µM;48 hours) promotes DNA fragmentation and causes apoptosis through inhibition of the p38 MAPK signaling pathway in SW480 cells[1]. 5-Geranoxy-7-methoxycoumarin (50 µM; 24-48 hours) increases the percentage of cells in the sub G1/G0 phase from 5.3% (in control cells) to 18% after 48 h incubation[1]. Cell Proliferation Assay[1] Cell Line: SW480 Concentration: 0-20 μM Incubation Time: 24, 48 and 72 hours Result: Inhibited cell growth by 67% at 72 hours. Apoptosis Analysis[1] Cell Line: SW480 cells Concentration: 50 μM Incubation Time: 48 hours Result: Induced cell apoptosis. Cell Cycle Analysis[1] Cell Line: SW480 cells Concentration: 50 μM Incubation Time: 48 hours Result: Inhibited cell cycle progression in vitro.
References

[1]. Jaiprakash R Patil, et al. 5-Geranyloxy-7-methoxycoumarin inhibits colon cancer (SW480) cells growth by inducing apoptosis. Planta Med. 2013 Mar;79(3-4):219-26.

[2]. Guo-Ying Zuo, et al. Synergism of coumarins from the Chinese drug Zanthoxylum nitidum with antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA). Phytomedicine

 Chemical & Physical Properties

Density 1.092g/cm3
Boiling Point 487.1ºC at 760 mmHg
Melting Point 86-88ºC
Molecular Formula C20H24O4
Molecular Weight 328.40
Flash Point 213.2ºC
Exact Mass 328.16700
PSA 48.67000
LogP 4.87310
Index of Refraction 1.542
Storage condition -20°C

 Synonyms

5-Geranoxy-7-methoxy-cumarin
5-geranyloxy-7-methoxycoumarin
5-Geranoxy-7-methoxycoumarin
7-Methoxy-5-geranoxycoumarin
Top Suppliers:I want be here


Get all suppliers and price by the below link:

5-Geranoxy-7-methoxycoumarin suppliers

5-Geranoxy-7-methoxycoumarin price