7380-39-4

7380-39-4 structure

Name: 5-Geranoxy-7-methoxycoumarin
Chemical Name: 5-[(2E)-3,7-dimethylocta-2,6-dienoxy]-7-methoxychromen-2-one
CAS Number: 7380-39-4
Molecular Formula: C₂₀H₂₄O₄
Molecular Weight: 328.40
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-08-28 16:39:07
Modify Date: 2024-01-03 22:13:40
5-Geranoxy-7-methoxycoumarin is a coumarin with anti-cancer, antifungal, and antibacterial activities. 5-Geranoxy-7-methoxycoumarin induces cell apoptosis[1][2].

Name	5-[(2E)-3,7-dimethylocta-2,6-dienoxy]-7-methoxychromen-2-one
Synonyms	5-Geranoxy-7-methoxy-cumarin 5-geranyloxy-7-methoxycoumarin 5-Geranoxy-7-methoxycoumarin 7-Methoxy-5-geranoxycoumarin

Description	5-Geranoxy-7-methoxycoumarin is a coumarin with anti-cancer, antifungal, and antibacterial activities. 5-Geranoxy-7-methoxycoumarin induces cell apoptosis[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	5-Geranoxy-7-methoxycoumarin (12.5-200 µM; 24-72 hours) induces a significant inhibition of cell growth in a time-dependent manner in SW480 cells[1]. 5-Geranoxy-7-methoxycoumarin (50 µM;48 hours) promotes DNA fragmentation and causes apoptosis through inhibition of the p38 MAPK signaling pathway in SW480 cells[1]. 5-Geranoxy-7-methoxycoumarin (50 µM; 24-48 hours) increases the percentage of cells in the sub G1/G0 phase from 5.3% (in control cells) to 18% after 48 h incubation[1]. Cell Proliferation Assay[1] Cell Line: SW480 Concentration: 0-20 μM Incubation Time: 24, 48 and 72 hours Result: Inhibited cell growth by 67% at 72 hours. Apoptosis Analysis[1] Cell Line: SW480 cells Concentration: 50 μM Incubation Time: 48 hours Result: Induced cell apoptosis. Cell Cycle Analysis[1] Cell Line: SW480 cells Concentration: 50 μM Incubation Time: 48 hours Result: Inhibited cell cycle progression in vitro.
References	[1]. Jaiprakash R Patil, et al. 5-Geranyloxy-7-methoxycoumarin inhibits colon cancer (SW480) cells growth by inducing apoptosis. Planta Med. 2013 Mar;79(3-4):219-26. [2]. Guo-Ying Zuo, et al. Synergism of coumarins from the Chinese drug Zanthoxylum nitidum with antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA). Phytomedicine

Density	1.092g/cm3
Boiling Point	487.1ºC at 760 mmHg
Melting Point	86-88ºC
Molecular Formula	C₂₀H₂₄O₄
Molecular Weight	328.40
Flash Point	213.2ºC
Exact Mass	328.16700
PSA	48.67000
LogP	4.87310
Index of Refraction	1.542
Storage condition	-20°C

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