β-Endorphin (30-31) (human)

Modify Date: 2024-01-08 12:09:16

β-Endorphin (30-31) (human) Structure
β-Endorphin (30-31) (human) structure
 Common Name β-Endorphin (30-31) (human)
CAS Number 7412-78-4 Molecular Weight 204.181
Density 1.4±0.1 g/cm3 Boiling Point 536.6±50.0 °C at 760 mmHg
Molecular Formula C7H12N2O5 Melting Point 155-158ºC (dec.)(lit.)
MSDS Chinese USA Flash Point 278.3±30.1 °C

 Use of β-Endorphin (30-31) (human)


Glycyl-L-glutamic acid is a neurotrophic factor (NF) in vivo, and exerts function of maintenance of AChE content and activity. Glycyl-L-glutamic acid doesn’t act directly on AChE synthesis, and may prevent preganglionic neuronal degeneration[1][2].

 Names

Name (2S)-2-[(2-aminoacetyl)amino]pentanedioic acid
Synonym More Synonyms

 β-Endorphin (30-31) (human) Biological Activity

Description Glycyl-L-glutamic acid is a neurotrophic factor (NF) in vivo, and exerts function of maintenance of AChE content and activity. Glycyl-L-glutamic acid doesn’t act directly on AChE synthesis, and may prevent preganglionic neuronal degeneration[1][2].
Related Catalog
Target

Acetylcholinesterase

References

[1]. Koelle GB, et al. Glycyl-L-glutamine, a precursor, and glycyl-L-glutamic acid, a neurotrophic factor for maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat in vivo. Proc Natl Acad Sci U S A. 1985 Aug;82(15):5213-7.

[2]. Yourick JJ, et al. Regeneration of acetylcholinesterase in clonal neuroblastoma-glioma hybrid NG108-15 cells after soman inhibition: effect of glycyl-L-glutamine. Cell Biol Toxicol. 1991 Jul;7(3):229-37.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 536.6±50.0 °C at 760 mmHg
Melting Point 155-158ºC (dec.)(lit.)
Molecular Formula C7H12N2O5
Molecular Weight 204.181
Flash Point 278.3±30.1 °C
Exact Mass 204.074615
PSA 129.72000
LogP -2.68
Vapour Pressure 0.0±3.1 mmHg at 25°C
Index of Refraction 1.537
Storage condition −20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Safety Phrases 24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2924199090

 Synthetic Route

Z-Gly-Glu-OH structure

Z-Gly-Glu-OH

CAS#:3916-39-0

~%

β-Endorphin (30-31) (human) Structure

β-Endorphin (30...

CAS#:7412-78-4

Literature: J. Gen. Chem. USSR (Engl. Transl.), , vol. 51, # 9 p. 1964 - 1971,1690 - 1695
N-Chloroacetylglutamic acid structure

N-Chloroacetylg...

CAS#:121704-20-9

~%

β-Endorphin (30-31) (human) Structure

β-Endorphin (30...

CAS#:7412-78-4

Literature: Justus Liebigs Annalen der Chemie, , vol. 365, p. 193,199
N-glycyl-L-glutamic acid diethyl ester structure

N-glycyl-L-glut...

CAS#:100100-97-8

~%

β-Endorphin (30-31) (human) Structure

β-Endorphin (30...

CAS#:7412-78-4

Literature: Helvetica Chimica Acta, , vol. 29, p. 1128,1130
diethyl glutamate structure

diethyl glutamate

CAS#:16450-41-2

~%

β-Endorphin (30-31) (human) Structure

β-Endorphin (30...

CAS#:7412-78-4

Literature: Helvetica Chimica Acta, , vol. 29, p. 1128,1130
N-(N,N-dibenzyl-glycyl)-L-glutamic acid structure

N-(N,N-dibenzyl...

CAS#:102446-49-1

~%

β-Endorphin (30-31) (human) Structure

β-Endorphin (30...

CAS#:7412-78-4

Literature: Bulletin de la Societe Chimique de France, , p. 1449,1452
H-Glu(OBzl)-OBzl structure

H-Glu(OBzl)-OBzl

CAS#:2768-50-5

~%

β-Endorphin (30-31) (human) Structure

β-Endorphin (30...

CAS#:7412-78-4

Literature: Agricultural and Biological Chemistry, , vol. 52, # 3 p. 871 - 872
D(-)-Glutamic acid structure

D(-)-Glutamic acid

CAS#:6893-26-1

~%

β-Endorphin (30-31) (human) Structure

β-Endorphin (30...

CAS#:7412-78-4

Literature: Justus Liebigs Annalen der Chemie, , vol. 365, p. 193,199
L-glutamic acid structure

L-glutamic acid

CAS#:56-86-0

Glycine structure

Glycine

CAS#:56-40-6

~%

β-Endorphin (30-31) (human) Structure

β-Endorphin (30...

CAS#:7412-78-4

Literature: J. Gen. Chem. USSR (Engl. Transl.), , vol. 37, # 8 p. 1761 - 1764,1677 - 1679

 Customs

HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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 Synonyms

L-Glutamic acid, N-glycyl-
N-glycylglutamic acid
H2N-glycine-Acide glutamique-OH
EINECS 231-019-4
H-Gly-Glu-OH
Glycylglutamic acid
Gly-L-Glu-OH
L-Glutamic acid,N-glycyl
GLY-GLU
MFCD00008128
Glycyl-L-glutamic acid
L-Glutamic acid, glycyl-
N-glycyl-L-glutamic acid
Gly-Glu-OH
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