3-Maleimidopropionic acid

Modify Date: 2024-01-02 11:47:04

3-Maleimidopropionic acid structure	Common Name	3-Maleimidopropionic acid
	CAS Number	7423-55-4	Molecular Weight	169.135
	Density	1.5±0.1 g/cm3	Boiling Point	382.5±25.0 °C at 760 mmHg
	Molecular Formula	C₇H₇NO₄	Melting Point	103-106 °C(lit.)
	MSDS	Chinese USA	Flash Point	185.1±23.2 °C
	Symbol	GHS07	Signal Word	Warning

Use of 3-Maleimidopropionic acid

3-Maleimidopropionic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	3-Maleimidopropionic Acid
Synonym	More Synonyms

Description	3-Maleimidopropionic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl-Chain
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density	1.5±0.1 g/cm3
Boiling Point	382.5±25.0 °C at 760 mmHg
Melting Point	103-106 °C(lit.)
Molecular Formula	C₇H₇NO₄
Molecular Weight	169.135
Flash Point	185.1±23.2 °C
Exact Mass	169.037506
PSA	74.68000
LogP	0.04
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.565
Storage condition	-15°C

3-Maleimidopropionic acid MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2925190090

Maleic anhydride

CAS#:108-31-6

beta-Alanine

CAS#:107-95-9

~83%

3-Maleimidoprop...

CAS#:7423-55-4

Literature: Han, Jing; Sun, Lidan; Chu, Yingying; Li, Zheng; Huang, Dandan; Zhu, Xiaoyun; Qian, Hai; Huang, Wenlong Journal of Medicinal Chemistry, 2013 , vol. 56, # 24 p. 9955 - 9968

CIS-5-AZA-4-OXO...

CAS#:57079-11-5

~12%

3-Maleimidoprop...

CAS#:7423-55-4

Literature: Veprek, Pavel; Hajduch, Marian; Dzubak, Petr; Kuklik, Rostislav; Polakova, Jana; Bezouska, Karel Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6400 - 6407

Maleic anhydride

CAS#:108-31-6

acetic acid

CAS#:64-19-7

beta-Alanine

CAS#:107-95-9

~48%

3-Maleimidoprop...

CAS#:7423-55-4

Literature: Yang, Hai-Kuan; Su, Ming-Ming; Ren, Li-Jun; Tang, Jing; Yan, Yu-Kun; Miao, Wen-Ke; Zheng, Ping; Wang, Wei European Journal of Inorganic Chemistry, 2013 , # 8 p. 1381 - 1389

Precursor 4
CAS#:108-31-6 Maleic anhydride CAS#:107-95-9 beta-Alanine CAS#:57079-11-5 CIS-5-AZA-4-OXO... CAS#:64-19-7 acetic acid
DownStream 4
CAS#:55750-62-4 N-Succinimidyl ... CAS#:57-13-6 Urea CAS#:22011-03-6 methyl 3-(2,5-d... CAS#:121215-45-0 propanoyl chlor...

HS Code	2925190090
Summary	2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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BMPA

β-Maleimidopropionic acid

MFCD00043030

3-(2,5-dioxopyrrol-1-yl)propanoic acid

3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoic acid

1H-Pyrrole-1-propanoic acid, 2,5-dihydro-2,5-dioxo-

3-Maleimidopropionic acid

3-Maleimidopropionicacid