10-Nitrolinoleic acid

Modify Date: 2024-01-05 11:21:16

10-Nitrolinoleic acid Structure
10-Nitrolinoleic acid structure
Common Name 10-Nitrolinoleic acid
CAS Number 774603-04-2 Molecular Weight 325.443
Density 1.0±0.1 g/cm3 Boiling Point 452.2±33.0 °C at 760 mmHg
Molecular Formula C18H31NO4 Melting Point N/A
MSDS N/A Flash Point 173.9±13.8 °C

 Use of 10-Nitrolinoleic acid


10-Nitrolinoleic acid is a potent peroxisome proliferator-activated receptor γ (PPARγ) agonist. 10-Nitrolinoleic acid competes with [3H]Rosiglitazone for binding to PPAR-γ, with an IC50 of 0.22 μM[1].

 Names

Name (9E,12Z)-10-nitrooctadeca-9,12-dienoic acid
Synonym More Synonyms

 10-Nitrolinoleic acid Biological Activity

Description 10-Nitrolinoleic acid is a potent peroxisome proliferator-activated receptor γ (PPARγ) agonist. 10-Nitrolinoleic acid competes with [3H]Rosiglitazone for binding to PPAR-γ, with an IC50 of 0.22 μM[1].
Related Catalog
Target

PPARγ:0.22 μM (IC50)

References

[1]. Dunny E, et, al. Stereocontrolled synthesis of the PPAR-gamma agonist 10-nitrolinoleic acid. J Org Chem. 2010 Aug 6;75(15):5334-6.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 452.2±33.0 °C at 760 mmHg
Molecular Formula C18H31NO4
Molecular Weight 325.443
Flash Point 173.9±13.8 °C
Exact Mass 325.225311
PSA 83.12000
LogP 6.10
Vapour Pressure 0.0±2.4 mmHg at 25°C
Index of Refraction 1.493
Storage condition -20℃

 Synonyms

(9E,12Z)-10-Nitro-9,12-octadecadienoic acid
9,12-Octadecadienoic acid, 10-nitro-, (9E,12Z)-
10-nitrolinoleic acid
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