Caspase-3/7 Inhibitor II

Modify Date: 2024-01-02 13:30:15

Caspase-3/7 Inhibitor II Structure
Caspase-3/7 Inhibitor II structure
Common Name Caspase-3/7 Inhibitor II
CAS Number 775289-20-8 Molecular Weight 501.488
Density 1.3±0.1 g/cm3 Boiling Point 1034.0±65.0 °C at 760 mmHg
Molecular Formula C20H31N5O10 Melting Point N/A
MSDS N/A Flash Point 579.1±34.3 °C

 Use of Caspase-3/7 Inhibitor II


Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) is a Caspase-3/7 inhibitor (IC50: 9.89, 245 nM respectively; Kiapp: 0.68, 55.7 nM respectively). Ac-DNLD-CHO can be used for research of caspase-mediated apoptosis diseases, such as neurodegenerative disorders and viral infection diseases[1].

 Names

Name N-Acetyl-L-α-aspartyl-L-asparaginyl-N-[(2S)-1-carboxy-3-oxo-2-propanyl]-L-leucinamide
Synonym More Synonyms

 Caspase-3/7 Inhibitor II Biological Activity

Description Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) is a Caspase-3/7 inhibitor (IC50: 9.89, 245 nM respectively; Kiapp: 0.68, 55.7 nM respectively). Ac-DNLD-CHO can be used for research of caspase-mediated apoptosis diseases, such as neurodegenerative disorders and viral infection diseases[1].
Related Catalog
Target

Caspase-3/7[1]

References

[1]. Yoshimori A, et al. Structural and functional definition of the specificity of a novel caspase-3 inhibitor, Ac-DNLD-CHO. BMC Pharmacol. 2007 Jun 27;7:8.  

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 1034.0±65.0 °C at 760 mmHg
Molecular Formula C20H31N5O10
Molecular Weight 501.488
Flash Point 579.1±34.3 °C
Exact Mass 501.207092
LogP -0.50
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.536

 Synonyms

L-Leucinamide, N-acetyl-L-α-aspartyl-L-asparaginyl-N-[(1S)-2-carboxy-1-formylethyl]-
N-Acetyl-L-α-aspartyl-L-asparaginyl-N-[(2S)-1-carboxy-3-oxo-2-propanyl]-L-leucinamide
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