Cycloastragenol

Modify Date: 2024-01-02 11:53:23

Cycloastragenol structure	Common Name	Cycloastragenol
	CAS Number	78574-94-4	Molecular Weight	490.715
	Density	1.2±0.1 g/cm3	Boiling Point	617.2±55.0 °C at 760 mmHg
	Molecular Formula	C₃₀H₅₀O₅	Melting Point	241.0 to 245.0 °C
	MSDS	Chinese USA	Flash Point	327.1±31.5 °C

Use of Cycloastragenol

Astramembrangenin (Cycloastragenol) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus (Fisch.) Bunge[1].Astramembrangenin is orally safe and has broad Extensive pharmacological effects, including telomerase activation, telomere elongation, anti-inflammatory and anti-oxidative properties[2].Astramembrangenin has antiaging properties, CAG stimulates telomerase activity in human neonatal keratinocytes and rat neuronal cells, and induces CREB activation followed by tert and bcl2 expression. Cycloastragenol (CAG) may have a novel therapeutic role in depression[2].

Name	Cycloastragenol
Synonym	More Synonyms

Description	Astramembrangenin (Cycloastragenol) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus (Fisch.) Bunge[1].Astramembrangenin is orally safe and has broad Extensive pharmacological effects, including telomerase activation, telomere elongation, anti-inflammatory and anti-oxidative properties[2].Astramembrangenin has antiaging properties, CAG stimulates telomerase activity in human neonatal keratinocytes and rat neuronal cells, and induces CREB activation followed by tert and bcl2 expression. Cycloastragenol (CAG) may have a novel therapeutic role in depression[2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
In Vitro	Astramembrangenin (0-10 µM; 3-6 days) increases cell growth compared to the vehicle control in HEK cultures[1]. Astramembrangenin (0.3 µM; 5-90 mins) induces CREB phosphorylation in primary cortical neurons, total CREB expression is unaltered by CAG in both cell type[1]. Astramembrangenin (3 µM; 6-48 hours) may promotes prosurvival signaling in neurons, increases tert mRNA expression, exhibits increased bcl2 mRNA expression[1]. Cell Viability Assay[1] Cell Line: HEK cells Concentration: 1 µM, 3 µM, 10 µM Incubation Time: 3-6 days Result: Doubled the cell growth at 6 days. Western Blot Analysis[1] Cell Line: Neuronal cells Concentration: 0.3 µM Incubation Time: 5 mins, 15 mins, 30 mins, 90 mins Result: Suggested that CAG induces CREB activation in neuronal cells. RT-PCR[1] Cell Line: Neuronal cells Concentration: 3 µM Incubation Time: 6-48 hours Result: Increased tert, bcl2 mRNA expression.
References	[1]. Ip FC, et al. Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management. Neurosignals. 2014;22(1):52-63. [2]. Yu Y, et al. Cycloastragenol: An exciting novel candidate for age-associated diseases. Exp Ther Med. 2018 Sep;16(3):2175-2182. [3]. Sun C, et al. Cycloastragenol mediates activation and proliferation suppression in concanavalin A-induced mouse lymphocyte pan-activation model. Immunopharmacol Immunotoxicol. 2017 Jun;39(3):131-139.

Density	1.2±0.1 g/cm3
Boiling Point	617.2±55.0 °C at 760 mmHg
Melting Point	241.0 to 245.0 °C
Molecular Formula	C₃₀H₅₀O₅
Molecular Weight	490.715
Flash Point	327.1±31.5 °C
Exact Mass	490.365814
PSA	90.15000
LogP	3.82
Vapour Pressure	0.0±4.0 mmHg at 25°C
Index of Refraction	1.582

RIDADR	NONH for all modes of transport
RTECS	GX8265000
HS Code	2942000000

HS Code	2942000000

Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management.

Neurosignals 22(1) , 52-63, (2014)

Cycloastragenol (CAG) is an aglycone of astragaloside IV. It was first identified when screening Astragalus membranaceus extracts for active ingredients with antiaging properties. The present study de...

A novel telomerase activator suppresses lung damage in a murine model of idiopathic pulmonary fibrosis.

PLoS ONE 8(3) , e58423, (2013)

The emergence of diseases associated with telomere dysfunction, including AIDS, aplastic anemia and pulmonary fibrosis, has bolstered interest in telomerase activators. We report identification of a n...

Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes.

J. Immunol. 181(10) , 7400-6, (2008)

Telomerase reverse transcribes telomere DNA onto the ends of linear chromosomes and retards cellular aging. In contrast to most normal somatic cells, which show little or no telomerase activity, immun...

9,19-Cyclolanostane-3,6,16,25-tetrol, 20,24-epoxy-, (3β,6α,9β,16β,20R,24S)-

Astramembrangenin

(3β,6α,9β,16β,20R,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol

9,19-Cyclolanostane-3,6,16,25-tetrol, 20,24-epoxy-, (3β,6α,9β,16β,20R,24R)-

Cycloastragenol

(3β,6α,9β,16β,20R,24S)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol

Cyclosieversigenin

Cyclogalegigenin