Pseudolaric acid B

Modify Date: 2024-01-04 23:58:03

Pseudolaric acid B Structure
Pseudolaric acid B structure
 Common Name Pseudolaric acid B
CAS Number 82508-31-4 Molecular Weight 432.464
Density 1.3±0.1 g/cm3 Boiling Point 613.8±55.0 °C at 760 mmHg
Molecular Formula C23H28O8 Melting Point 166°C
MSDS USA Flash Point 208.8±25.0 °C
Symbol GHS06 GHS08
GHS06, GHS08		 Signal Word Danger

 Use of Pseudolaric acid B


Pseudolaric Acid B is a diterpene isolated from the root of Pseudolarix kaempferi Gorden (pinaceae), has anti-cancer, antifungal, and antifertile activities, and shows immunosuppressive activity on T lymphocytes[1][2][3]. Pseudolaric Acid B inhibits hepatitis B virus (HBV) secretion through apoptosis and cell cycle arrest. Pseudolaric Acid B induces autophagy[4][5].

 Names

Name pseudolaric acid b
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 613.8±55.0 °C at 760 mmHg
Melting Point 166°C
Molecular Formula C23H28O8
Molecular Weight 432.464
Flash Point 208.8±25.0 °C
Exact Mass 432.178406
PSA 116.20000
LogP 2.78
Appearance of Characters white to off-white
Vapour Pressure 0.0±3.8 mmHg at 25°C
Index of Refraction 1.565
Storage condition 2-8°C
Water Solubility methanol: soluble1mg/mL, clear, colorless

 Safety Information

Symbol GHS06 GHS08
GHS06, GHS08
Signal Word Danger
Hazard Statements H301-H361
Precautionary Statements P281-P301 + P310
Hazard Codes T
Risk Phrases 25-62
Safety Phrases 36/37-45-24/25
RIDADR UN 2811 6.1 / PGIII

 Synthetic Route

(1R,7S,8S,9S)-7-acetoxy-9-ethynyl-9-methyl-11-oxo-10-oxa-tricyclo[6.3.2.01,7]tridec-3-ene-4-carboxylic acid methyl ester structure

(1R,7S,8S,9S)-7...

CAS#:1000669-90-8

3-iodo-2-methylprop-2-enoic acid structure

3-iodo-2-methyl...

CAS#:128836-43-1

~62%

Pseudolaric acid B Structure

Pseudolaric acid B

CAS#:82508-31-4

Literature: Trost, Barry M.; Waser, Jerome; Meyer, Arndt Journal of the American Chemical Society, 2008 , vol. 130, # 48 p. 16424 - 16434
methyl (3R,4R,4aS,9aR)-4a-hydroxy-3-((1E,3E)-5-hydroxy-4-methylpenta-1,3-dien-1-yl)-3-methyl-1-oxo-3,4,4a,5,6,9-hexahydro-1H-4,9a-ethanocyclohepta[c]pyran-7-carboxylate structure

methyl (3R,4R,4...

CAS#:457622-28-5

~%

Pseudolaric acid B Structure

Pseudolaric acid B

CAS#:82508-31-4

Literature: Tetrahedron Letters, , vol. 43, # 22 p. 4095 - 4098
N/A structure

N/A

CAS#:457622-29-6

~%

Pseudolaric acid B Structure

Pseudolaric acid B

CAS#:82508-31-4

Literature: Tetrahedron Letters, , vol. 43, # 22 p. 4095 - 4098
methyl (3S,4R,4aS,7S,9aR)-3-formyl-4a-hydroxy-3-methyl-1-oxooctahydro-1H-4,9a-ethanocyclohepta[c]pyran-7-carboxylate structure

methyl (3S,4R,4...

CAS#:457622-27-4

~%

Pseudolaric acid B Structure

Pseudolaric acid B

CAS#:82508-31-4

Literature: Tetrahedron Letters, , vol. 43, # 22 p. 4095 - 4098
methyl (3S,4R,4aS,7S,9aR)-4a-acetoxy-3-formyl-3-methyl-1-oxooctahydro-1H-4,9a-ethanocyclohepta[c]pyran-7-carboxylate structure

methyl (3S,4R,4...

CAS#:457622-33-2

~%

Pseudolaric acid B Structure

Pseudolaric acid B

CAS#:82508-31-4

Literature: Tetrahedron Letters, , vol. 43, # 22 p. 4095 - 4098
methyl (3R,4R,4aS,7S,9aR)-4a-hydroxy-3-methyl-1-oxo-3-((E)-3-oxoprop-1-en-1-yl)octahydro-1H-4,9a-ethanocyclohepta[c]pyran-7-carboxylate structure

methyl (3R,4R,4...

CAS#:457622-30-9

~%

Pseudolaric acid B Structure

Pseudolaric acid B

CAS#:82508-31-4

Literature: Tetrahedron Letters, , vol. 43, # 22 p. 4095 - 4098
methyl (3R,4R,4aS,7S,9aR)-4a-hydroxy-3-((E)-3-hydroxyprop-1-en-1-yl)-3-methyl-1-oxooctahydro-1H-4,9a-ethanocyclohepta[c]pyran-7-carboxylate structure

methyl (3R,4R,4...

CAS#:457622-31-0

~%

Pseudolaric acid B Structure

Pseudolaric acid B

CAS#:82508-31-4

Literature: Tetrahedron Letters, , vol. 43, # 22 p. 4095 - 4098

 Articles22

More Articles
Newly discovered angiogenesis inhibitors and their mechanisms of action.

Acta Pharmacol. Sin. 33(9) , 1103-11, (2012)

In the past decade, the success of angiogenesis inhibitors in clinical contexts has established the antiangiogenic strategy as an important part of cancer therapy. During that time period, we have dis...

Bcl-2 family proteins were involved in pseudolaric acid B-induced autophagy in murine fibrosarcoma L929 cells.

J. Pharmacol. Sci. 107(3) , 295-302, (2008)

Pseudolaric acid B (PAB) exerted cytostatic activity on murine fibrosarcoma L929 cells. The cytostatic mechanism of PAB on L929 cells was investigated in this paper. At 36 h, after 80 microM PAB treat...

In vitro synergy of pseudolaric acid B and fluconazole against clinical isolates of Candida albicans.

Mycoses 54(5) , e400-6, (2011)

Candida albicans is the most common fungal pathogen in humans. The emergence of resistance to azole antifungals has raised the issue of using such antifungals in combination to optimise therapeutic ou...

 Synonyms

(2E,4E)-5-[(1R,7S,8R,9R)-4,7-Bis(methoxycarbonyl)-9-methyl-11-oxo-10-oxatricyclo[6.3.2.0]tridec-3-en-9-yl]-2-methylpenta-2,4-dienoic acid
(2E,4E)-5-[(1S,7S,8S,9R)-7-Acetoxy-4-(methoxycarbonyl)-9-methyl-11-oxo-10-oxatricyclo[6.3.2.0]tridec-3-en-9-yl]-2-methyl-2,4-pentadienoic acid
1H-4,9a-Ethanocyclohepta[c]pyran-7-carboxylic acid, 4a-(acetyloxy)-3-[(1E,3E)-4-carboxy-1,3-pentadien-1-yl]-3,4,4a,5,6,9-hexahydro-3-methyl-1-oxo-, 7-methyl ester, (3R,4S,4aS,9aS)-
(2E,4E)-5-[(1R,7S,8R,9R)-4,7-Bis(methoxycarbonyl)-9-methyl-11-oxo-10-oxatricyclo[6.3.2.0]tridec-3-en-9-yl]-2-methyl-2,4-pentadienoic acid
1H-4,9a-Ethanocyclohepta[c]pyran-4a,7(5H)-dicarboxylic acid, 3-[(1E,3E)-4-carboxy-1,3-pentadien-1-yl]-3,4,6,9-tetrahydro-3-methyl-1-oxo-, 4a,7-dimethyl ester, (3R,4R,4aS,9aR)-
PLAB
(2E,4E)-5-[(1S,7S,8S,9R)-7-Acetoxy-4-(methoxycarbonyl)-9-methyl-11-oxo-10-oxatricyclo[6.3.2.0]tridec-3-en-9-yl]-2-methylpenta-2,4-dienoic acid
PseudolaricAcidB
Pseudolarix acid B
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Chemsrc provides Pseudolaric acid B(CAS#:82508-31-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Pseudolaric acid B are included as well.>> amp version: Pseudolaric acid B

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