AT-1002

Modify Date: 2024-01-12 19:04:54

AT-1002 structure	Common Name	AT-1002
	CAS Number	835872-35-0	Molecular Weight	707.88
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₂H₅₃N₉O₇S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of AT-1002

AT-1002, a 6-mer synthetic peptide[1], is a tight junction regulator and absorption enhancer[2].

Name	(2S)-2-[[(2S)-2-[[2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-sulfanylpropanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoic acid
Synonym	More Synonyms

Description	AT-1002, a 6-mer synthetic peptide[1], is a tight junction regulator and absorption enhancer[2].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Cytoskeleton >> Gap Junction Protein
In Vitro	AT-1002 a 6-mer synthetic peptide belongs to an emerging novel class of compounds that reversibly increase paracellular transport of molecules across the epithelial barrier. AT-1002 can undergo Cys-Cys dimerization[1]. Undifferentiated Caco-2 cells are treated with AT-1002 and viability is assessed by measuring cellular ATP content. Treatment with AT-1002 for up to 3 h does not affect cell viability at any concentration. In particular, the viability of Caco-2 cells is not affected by 5 mg/mL AT-1002. AT-1002 reduces cell viability after 24 h at concentrations of 2.5 mg/mL and higher. However, the cells remain viable after 24 h if the cells are washed after exposure to AT-1002 for 3 h indicating that AT-1002 does not irreversibly damage cells[2]. AT-1002 treatment results in 3-fold increase in phosphotyrosine content of zonula occludens-1 (ZO-1)[2].
References	[1]. Li M, et al. Structure-activity relationship studies of permeability modulating peptide AT-1002. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4584-6. [2]. Gopalakrishnan S, et al. Mechanism of action of ZOT-derived peptide AT-1002, a tight junction regulator and absorption enhancer. Int J Pharm. 2009 Jan 5;365(1-2):121-30.

Molecular Formula	C₃₂H₅₃N₉O₇S
Molecular Weight	707.88
Exact Mass	707.37900
PSA	326.97000
LogP	5.07440

AT-1002

L-Leucine,L-phenylalanyl-L-cysteinyl-L-isoleucylglycyl-L-arginyl

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: AT-1002
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: AT-1002
Price: $550.0/100mg $950.0/250mg $1800.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: AT-1002
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

Taiwan Oyi peptide Co. Ltd
China
Product Name: AT-1002
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Delivery: 1 Day
Contact: Vinnie
Email: Jamie@api-made.com

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