835872-35-0

835872-35-0 structure

Name: AT-1002
Chemical Name: (2S)-2-[[(2S)-2-[[2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-sulfanylpropanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoic acid
CAS Number: 835872-35-0
Molecular Formula: C₃₂H₅₃N₉O₇S
Molecular Weight: 707.88
Catalog: Signaling Pathways Cytoskeleton Gap Junction Protein
Create Date: 2016-11-22 15:34:11
Modify Date: 2024-01-12 19:04:54
AT-1002, a 6-mer synthetic peptide[1], is a tight junction regulator and absorption enhancer[2].

Name	(2S)-2-[[(2S)-2-[[2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-sulfanylpropanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoic acid
Synonyms	AT-1002 L-Leucine,L-phenylalanyl-L-cysteinyl-L-isoleucylglycyl-L-arginyl

Description	AT-1002, a 6-mer synthetic peptide[1], is a tight junction regulator and absorption enhancer[2].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Cytoskeleton >> Gap Junction Protein
In Vitro	AT-1002 a 6-mer synthetic peptide belongs to an emerging novel class of compounds that reversibly increase paracellular transport of molecules across the epithelial barrier. AT-1002 can undergo Cys-Cys dimerization[1]. Undifferentiated Caco-2 cells are treated with AT-1002 and viability is assessed by measuring cellular ATP content. Treatment with AT-1002 for up to 3 h does not affect cell viability at any concentration. In particular, the viability of Caco-2 cells is not affected by 5 mg/mL AT-1002. AT-1002 reduces cell viability after 24 h at concentrations of 2.5 mg/mL and higher. However, the cells remain viable after 24 h if the cells are washed after exposure to AT-1002 for 3 h indicating that AT-1002 does not irreversibly damage cells[2]. AT-1002 treatment results in 3-fold increase in phosphotyrosine content of zonula occludens-1 (ZO-1)[2].
References	[1]. Li M, et al. Structure-activity relationship studies of permeability modulating peptide AT-1002. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4584-6. [2]. Gopalakrishnan S, et al. Mechanism of action of ZOT-derived peptide AT-1002, a tight junction regulator and absorption enhancer. Int J Pharm. 2009 Jan 5;365(1-2):121-30.