HO-PEG5-CH2CH2COOtBu

Modify Date: 2024-01-22 14:36:24

HO-PEG5-CH2CH2COO<sup>t</sup>Bu structure	Common Name	HO-PEG5-CH2CH2COO<sup>t</sup>Bu
	CAS Number	850090-09-4	Molecular Weight	366.44700
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₃₄O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HO-PEG5-CH2CH2COOtBu

Hydroxy-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-Methyl-2-propanyl 1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oa te
Synonym	More Synonyms

Description	Hydroxy-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Pentaethylene glycol

CAS#:4792-15-8

tert-Butyl acrylate

CAS#:1663-39-4

~81%

HO-PEG5-CH2CH2C...

CAS#:850090-09-4

Literature: Wosnick, Jordan H.; Mello, Charlene M.; Swager, Timothy M. Journal of the American Chemical Society, 2005 , vol. 127, # 10 p. 3400 - 3405

Precursor 2
CAS#:4792-15-8 Pentaethylene glycol CAS#:1663-39-4 tert-Butyl acrylate
DownStream 0

18-Hydroxy-19-norcorticosterone

18-hydroxy-4,7,10,13,16-pentaoxaoctadecanoic acid tert-butyl ester

18-OH-19-NC

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