Choline Fenofibrate

Modify Date: 2024-01-08 09:50:58

Choline Fenofibrate structure	Common Name	Choline Fenofibrate
	CAS Number	856676-23-8	Molecular Weight	421.91400
	Density	N/A	Boiling Point	486.5ºC at 760 mmHg
	Molecular Formula	C₂₂H₂₈ClNO₅	Melting Point	N/A
	MSDS	N/A	Flash Point	248ºC

Use of Choline Fenofibrate

Choline Fenofibrate (ABT-335) is the choline salt of fenofibric acid under clinical development as a combination therapy with rosuvastatin for the management of dyslipidemia. IC50 value:Target:Several clinical trials have been developed with Choline Fenofibrate on Reverse Cholesterol Transport, Macular Edema and Hypertriglyceridemia.

Name	2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate,2-hydroxyethyl(trimethyl)azanium
Synonym	More Synonyms

Description	Choline Fenofibrate (ABT-335) is the choline salt of fenofibric acid under clinical development as a combination therapy with rosuvastatin for the management of dyslipidemia. IC50 value:Target:Several clinical trials have been developed with Choline Fenofibrate on Reverse Cholesterol Transport, Macular Edema and Hypertriglyceridemia.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Cardiovascular Disease
References	[1]. Jones PH, Bays HE, Davidson MH et al. Evaluation of a new formulation of fenofibric acid, ABT-335, co-administered with statins : study design and rationale of a phase III clinical programme. Clin Drug Investig. 2008;28(10):625-34. [2]. Mohiuddin SM, Pepine CJ, Kelly MT et al. Efficacy and safety of ABT-335 (fenofibric acid) in combination with simvastatin in patients with mixed dyslipidemia: a phase 3, randomized, controlled study. Am Heart J. 2009 Jan;157(1):195-203. [3]. Zhu T, Awni WM, Hosmane B et al. ABT-335, the choline salt of fenofibric acid, does not have a clinically significant pharmacokinetic interaction with rosuvastatin in humans. J Clin Pharmacol. 2009 Jan;49(1):63-71. [4]. Goldberg AC, Bays HE, Ballantyne CM et al. Efficacy and safety of ABT-335 (fenofibric acid) in combination with atorvastatin in patients with mixed dyslipidemia. Am J Cardiol. 2009 Feb 15;103(4):515-22. [5]. Campbell J, Mohiuddin SM. The role of a new formulation of fenofibric acid in the treatment of mixed dyslipidemia in type 2 diabetes. Drugs Today (Barc). 2010 Oct;46(10):757-64.

Description

Related Catalog

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

Research Areas >> Cardiovascular Disease

References

[1]. Jones PH, Bays HE, Davidson MH et al. Evaluation of a new formulation of fenofibric acid, ABT-335, co-administered with statins : study design and rationale of a phase III clinical programme. Clin Drug Investig. 2008;28(10):625-34.

[2]. Mohiuddin SM, Pepine CJ, Kelly MT et al. Efficacy and safety of ABT-335 (fenofibric acid) in combination with simvastatin in patients with mixed dyslipidemia: a phase 3, randomized, controlled study. Am Heart J. 2009 Jan;157(1):195-203.

[3]. Zhu T, Awni WM, Hosmane B et al. ABT-335, the choline salt of fenofibric acid, does not have a clinically significant pharmacokinetic interaction with rosuvastatin in humans. J Clin Pharmacol. 2009 Jan;49(1):63-71.

[4]. Goldberg AC, Bays HE, Ballantyne CM et al. Efficacy and safety of ABT-335 (fenofibric acid) in combination with atorvastatin in patients with mixed dyslipidemia. Am J Cardiol. 2009 Feb 15;103(4):515-22.

[5]. Campbell J, Mohiuddin SM. The role of a new formulation of fenofibric acid in the treatment of mixed dyslipidemia in type 2 diabetes. Drugs Today (Barc). 2010 Oct;46(10):757-64.

Boiling Point	486.5ºC at 760 mmHg
Molecular Formula	C₂₂H₂₈ClNO₅
Molecular Weight	421.91400
Flash Point	248ºC
Exact Mass	421.16600
PSA	86.66000
LogP	2.16320
Storage condition	2-8℃

Ethyl 2-bromois...

CAS#:600-00-0

4-p-Chlorobenzo...

CAS#:42019-78-3

Choline Hydroxide

CAS#:123-41-1

~70%

Choline Fenofibrate

CAS#:856676-23-8

Literature: US2008/275270 A1, ; Page/Page column 3 ;

Fenofibric acid

CAS#:42017-89-0

Choline chloride

CAS#:67-48-1

~75%

Choline Fenofibrate

CAS#:856676-23-8

Literature: WO2010/86700 A2, ; Page/Page column 7 ;

Isopropyl 2-bro...

CAS#:51368-55-9

4-p-Chlorobenzo...

CAS#:42019-78-3

Choline Hydroxide

CAS#:123-41-1

~68%

Choline Fenofibrate

CAS#:856676-23-8

Literature: US2008/275270 A1, ; Page/Page column 3 ;

Precursor 6
CAS#:600-00-0 Ethyl 2-bromois... CAS#:42019-78-3 4-p-Chlorobenzo... CAS#:123-41-1 Choline Hydroxide CAS#:42017-89-0 Fenofibric acid
CAS#:67-48-1 Choline chloride CAS#:51368-55-9 Isopropyl 2-bro...
DownStream 0

Choline fenofibrate

UNII-4BMH7IZT98

fenofibric acid choline salt

ABT-335

Fenofibrate de choline

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Choline Fenofibrate
Price: Negotiable
Purity: 99.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Choline Fenofibrate;ABT-335
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: Choline Fenofibrate;ABT-335
Price: $450.0/100mg $900.0/250mg $1800.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Choline fenofibrate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Unii-4bmh7izt98 856676-23-8
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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Price: ￥307/1g

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