非诺贝特酸胆碱盐

• 常用名: 非诺贝特酸胆碱盐
• 英文名: Choline Fenofibrate
• CAS号: 856676-23-8
• 分子量: 421.91400
• 密度: N/A
• 沸点: 486.5ºC at 760 mmHg
• 分子式: C₂₂H₂₈ClNO₅
• 熔点: N/A
• 闪点: 248ºC

非诺贝特酸胆碱盐用途

Choline Fenofibrate (ABT-335)是fenofibric acid的胆碱盐,可与rosuvastatin结合作用于血脂异常。

非诺贝特酸胆碱盐名称

• 中文名: 非诺贝特酸胆碱盐
• 英文名: 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate,2-hydroxyethyl(trimethyl)azanium
• 中文别名: 胆碱非诺贝特

非诺贝特酸胆碱盐生物活性

• 描述: Choline Fenofibrate (ABT-335)是fenofibric acid的胆碱盐,可与rosuvastatin结合作用于血脂异常。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Jones PH, Bays HE, Davidson MH et al. Evaluation of a new formulation of fenofibric acid, ABT-335, co-administered with statins : study design and rationale of a phase III clinical programme. Clin Drug Investig. 2008;28(10):625-34.

  [2]. Mohiuddin SM, Pepine CJ, Kelly MT et al. Efficacy and safety of ABT-335 (fenofibric acid) in combination with simvastatin in patients with mixed dyslipidemia: a phase 3, randomized, controlled study. Am Heart J. 2009 Jan;157(1):195-203.

  [3]. Zhu T, Awni WM, Hosmane B et al. ABT-335, the choline salt of fenofibric acid, does not have a clinically significant pharmacokinetic interaction with rosuvastatin in humans. J Clin Pharmacol. 2009 Jan;49(1):63-71.

  [4]. Goldberg AC, Bays HE, Ballantyne CM et al. Efficacy and safety of ABT-335 (fenofibric acid) in combination with atorvastatin in patients with mixed dyslipidemia. Am J Cardiol. 2009 Feb 15;103(4):515-22.

  [5]. Campbell J, Mohiuddin SM. The role of a new formulation of fenofibric acid in the treatment of mixed dyslipidemia in type 2 diabetes. Drugs Today (Barc). 2010 Oct;46(10):757-64.

非诺贝特酸胆碱盐物理化学性质

• 沸点: 486.5ºC at 760 mmHg
• 分子式: C₂₂H₂₈ClNO₅
• 分子量: 421.91400
• 闪点: 248ºC
• 精确质量: 421.16600
• PSA: 86.66000
• LogP: 2.16320
• 储存条件: 2-8℃

非诺贝特酸胆碱盐英文别名

• Choline fenofibrate
• UNII-4BMH7IZT98
• fenofibric acid choline salt
• ABT-335
• Fenofibrate de choline