3-(Methylselanyl)-L-alanine hydrochloride (1:1)

Modify Date: 2024-01-05 00:43:14

3-(Methylselanyl)-L-alanine hydrochloride (1:1) structure	Common Name	3-(Methylselanyl)-L-alanine hydrochloride (1:1)
	CAS Number	863394-07-4	Molecular Weight	218.54
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄H₁₀ClNO₂Se	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS06, GHS08, GHS09	Signal Word	Danger

Use of 3-(Methylselanyl)-L-alanine hydrochloride (1:1)

Se-Methylselenocysteine hydrochloride, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine hydrochloride is orally bioavailable, and induces apoptosis[1][2].

Name	(2R)-2-amino-3-methylselanylpropanoic acid,hydrochloride
Synonym	More Synonyms

Description	Se-Methylselenocysteine hydrochloride, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine hydrochloride is orally bioavailable, and induces apoptosis[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Neuronal Signaling >> Beta-secretase
References	[1]. Yeo JK, et al. Se-methylselenocysteine induces apoptosis through caspase activation and Bax cleavage mediated by calpain in SKOV-3 ovarian cancer cells. Cancer Lett. 2002 Aug 8;182(1):83-92. [2]. Cao S, et al. Se-methylselenocysteine offers selective protection against toxicity and potentiates the antitumour activity of anticancer drugs in preclinical animal models. Br J Cancer. 2014 Apr 2;110(7):1733-43. [3]. Xie Y, et al. Se-Methylselenocysteine Ameliorates Neuropathology and Cognitive Deficits by Attenuating Oxidative Stress and Metal Dyshomeostasis in Alzheimer Model Mice. Mol Nutr Food Res. 2018 Jun;62(12):e1800107.

Description

Related Catalog

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Neuronal Signaling >> Beta-secretase

References

[1]. Yeo JK, et al. Se-methylselenocysteine induces apoptosis through caspase activation and Bax cleavage mediated by calpain in SKOV-3 ovarian cancer cells. Cancer Lett. 2002 Aug 8;182(1):83-92.

[2]. Cao S, et al. Se-methylselenocysteine offers selective protection against toxicity and potentiates the antitumour activity of anticancer drugs in preclinical animal models. Br J Cancer. 2014 Apr 2;110(7):1733-43.

[3]. Xie Y, et al. Se-Methylselenocysteine Ameliorates Neuropathology and Cognitive Deficits by Attenuating Oxidative Stress and Metal Dyshomeostasis in Alzheimer Model Mice. Mol Nutr Food Res. 2018 Jun;62(12):e1800107.

Molecular Formula	C₄H₁₀ClNO₂Se
Molecular Weight	218.54
Exact Mass	218.956528
PSA	63.32000
LogP	1.07120
Storage condition	20°C

MSDS(Chinese)

Symbol	GHS06, GHS08, GHS09
Signal Word	Danger
Hazard Statements	H301-H331-H373-H410
Precautionary Statements	P261-P273-P301 + P310-P311-P501
Hazard Codes	T
RIDADR	UN 3283 6.1 / PGII
HS Code	2922499990

HS Code	2922499990
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Distribution of selenium in zebrafish larvae after exposure to organic and inorganic selenium forms.

Metallomics 8 , 305-12, (2016)

Selenium is an essential micronutrient for many organisms, and in vertebrates has a variety of roles associated with protection from reactive oxygen species. Over the past two decades there have been ...

Regulation of the extracellular antioxidant selenoprotein plasma glutathione peroxidase (GPx-3) in mammalian cells.

Mol. Cell Biochem. 327 , 111-26, (2009)

Plasma glutathione peroxidase (GPx-3) is a selenocysteine-containing extracellular antioxidant protein that catalyzes the reduction of hydrogen peroxide and lipid hydroperoxides. Selenoprotein express...

Se-MSC

M 6680

L-Alanine, 3-(methylseleno)-, hydrochloride (1:1)

3-(Methylselanyl)-L-alanine hydrochloride (1:1)