Albanol B

Modify Date: 2024-01-03 00:01:42

Albanol B Structure
Albanol B structure
Common Name Albanol B
CAS Number 87084-99-9 Molecular Weight 558.53
Density 1.554g/cm3 Boiling Point 828.2ºC at 760 mmHg
Molecular Formula C34H22O8 Melting Point N/A
MSDS N/A Flash Point 454.7ºC

 Use of Albanol B


Albanol B is an arylbenzofuran derivative which can be isolated from mulberries. Albanol B exhibits anti-Alzheimer's disease, anti-bacterial and antioxidant activities. Albanol B inhibits cancer cells proliferation, down-regulates CDK1 expression. Albanol B also induces cell cycle arrest at G2/M and apoptosis. And Albanol B induces mitochondrial ROS production and increases the phosphorylation levels of AKT and ERK1/2[1].

 Names

Name Albanol B
Synonym More Synonyms

 Albanol B Biological Activity

Description Albanol B is an arylbenzofuran derivative which can be isolated from mulberries. Albanol B exhibits anti-Alzheimer's disease, anti-bacterial and antioxidant activities. Albanol B inhibits cancer cells proliferation, down-regulates CDK1 expression. Albanol B also induces cell cycle arrest at G2/M and apoptosis. And Albanol B induces mitochondrial ROS production and increases the phosphorylation levels of AKT and ERK1/2[1].
Related Catalog
In Vitro Albanol B(10 μM,30 μM;24 小时)降低 A549 细胞的细胞活力[1]。 Albanol B(30 μM;48 小时)抑制 A549 和 H1975 细胞的 G2/M 期细胞周期并诱导细胞凋亡[1]。 Albanol B(1-30 μM;1-9 小时)介导 A549 细胞中 ERK-1/2 和 AKT 的激活[1]。 Cell Viability Assay[1] Cell Line: A549 cells, BZR, NCI-H1975, and NCI-H226 cells Concentration: 0, 1, 3, 10, and 30 μM Incubation Time: 48 hours Result: Exhibited inhibitory effects on cancer cells with IC50s of 5.6 μM (A549), 8.9 μM (BZR), 12.7 μM (NCI-H1975), and 15 μM (NCI-H226), respectively. Cell Cycle Analysis[1] Cell Line: A549 and H1975 cells Concentration: 1, 3, 10 μM Incubation Time: 48 hours Result: Increased cells in G2/M phase from 9.5% to 14.34%, 18.13% and 47.9%, respectively. Western Blot Analysis[1] Cell Line: A549 cells Concentration: 1 h, 3 h, 6 h, and 9 h Incubation Time: 48 hours Result: Increased the phosphorylation levels of ERK1/2 and AKT in time- and concentration-dependent manners. Did not increase the phosphorylation level of JNK and p38 MAPKs.
In Vivo Albanol B(50 mg/kg、100 mg/kg;腹腔注射;每天一次,持续 21 天)抑制 Ex-3LL 荷瘤小鼠的肿瘤生长[1]。 Animal Model: EX-3LL tumor-bearing mice[1] Dosage: 50 mg/kg, 100 mg/kg Administration: IP; once daily for 21 days Result: Decreased tumor volume and weight by 48.0% and 41.0% (for 50 mg/kg treatment), and 61.3% and 57.3% (for 100 mg/kg treatment), respectively.
References

[1]. Phan TN, et al. Albanol B from Mulberries Exerts Anti-Cancer Effect through Mitochondria ROS Production in Lung Cancer Cells and Suppresses In Vivo Tumor Growth. Int J Mol Sci. 2020 Dec 14;21(24):9502.  

 Chemical & Physical Properties

Density 1.554g/cm3
Boiling Point 828.2ºC at 760 mmHg
Molecular Formula C34H22O8
Molecular Weight 558.53
Flash Point 454.7ºC
Exact Mass 558.13100
PSA 132.75000
LogP 7.25610
Index of Refraction 1.796

 Synthetic Route

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Albanol B Structure

Albanol B

CAS#:87084-99-9

Literature: Hano, Yoshio; Miyagawa, Yoko; Yano, Mamiko; Nomura, Taro Heterocycles, 1989 , vol. 28, # 2 p. 745 - 750

 Synonyms

(+/-)-albanol B
8aH-Benzo[3,4][2]benzopyrano[1,8-bc][1]-benzopyran-4,11-diol,8a-(2,4-dihydroxyphenyl)-6-(6-hydroxy-2-benzofuranyl)-2-methyl-,(8aR)