ZK 756326
Modify Date: 2024-01-03 06:12:38
ZK 756326 structure
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Common Name | ZK 756326 | ||
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| CAS Number | 874911-96-3 | Molecular Weight | 356.46 | |
| Density | 1.142±0.06 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C21H28N2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ZK 756326ZK756326 is a nonpeptide chemokine receptor agonist for the CC chemokine receptor CCR8. |
| Name | 2-[2-[4-[(3-phenoxyphenyl)methyl]-1-piperazinyl]ethoxy]ethanoldihydrochloride |
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| Synonym | More Synonyms |
| Description | ZK756326 is a nonpeptide chemokine receptor agonist for the CC chemokine receptor CCR8. |
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| Related Catalog | |
| Target |
IC50: 1.8 μM (CCR8)[1] |
| Cell Assay | U87 MG cells expressing CCR8 are plated on poly-D-lysine-coated black 96-well plates at 10,000 cells/well and are cultured overnight. Cells are then loaded with Calcium 3, a Ca2+-sensitive non-wash fluorescence dye, for 60 min at 37°C in Hanks' balanced salts solution containing 20 mM HEPES, 3.2 mM CaCl2, 1% (v/v) fetal bovine serum, and 2.5 mM probenecid. Changes in intracellular free-Ca2+ concentration are measured with Fluorometric Imaging Plate Reader (FLIPR 3) immediately after the addition of agonist at room temperature. Cross-desensitization experiments are performed by a first addition of the agonist (CCL1 at 30 nM or ZK 756326 at 3 μM), immediately followed by a second addition of 100 nM CCL1[1]. |
| References |
| Density | 1.142±0.06 g/cm3 |
|---|---|
| Molecular Formula | C21H28N2O3 |
| Molecular Weight | 356.46 |
| Exact Mass | 428.16300 |
| PSA | 45.17000 |
| LogP | 4.08520 |
| Storage condition | -20℃ |
| Water Solubility | Slightly soluble (3 g/L) (25 ºC) |
| 2-[2-[4-[(3-Phenoxyphenyl)methyl]-1-piperazinyl]ethoxy]ethanol |
| ZK 756326 |
| MFCD09038571 |