RF 9 TFA

Modify Date: 2024-01-02 16:13:12

RF 9 TFA structure	Common Name	RF 9 TFA
	CAS Number	876310-60-0	Molecular Weight	482.62
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₃₈N₆O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of RF 9 TFA

RF9 is a potent and selective Neuropeptide FF receptor antagonist, with Kis of 58±5 and 75±9 nM for hNPFF1R and hNPFF2R, respectively.

Name	rf 9
Synonym	More Synonyms

Description	RF9 is a potent and selective Neuropeptide FF receptor antagonist, with Kis of 58±5 and 75±9 nM for hNPFF1R and hNPFF2R, respectively.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor Research Areas >> Cardiovascular Disease Research Areas >> Neurological Disease
Target	Ki: 58±5 nM (hNPFF1R), 75±9 nM (hNPFF2R)[1]
In Vivo	RF9 (10 μg) infused alone does not result in a significant alteration of MAP or heart rate. Conversely, MAP and heart rate increases evoked by NPFF are significantly blocked when NPFF is applied in conjunction with RF9[1]. It is worthy to note that RF9 (30 nmol) significantly reduces the hypothermia induced by morphine (5 nmol)[2].
Animal Admin	Rats: Rats (n=5) are catheterized for measurement of arterial blood pressure and receive an in-dwelling cannula into the lateral cerebral ventricle. Arterial blood pressure and heart rate are continuously monitored. NPFF (10 μg in 10 μL of saline) is injected into the lateral ventricle over 15 to 20 sec. Control injections of saline (10 μL) are carried out in the same animals. Upon return of blood pressure to baseline, RF9 (10 μg) is injected i.c.v., followed by another i.c.v. injection of NPFF with RF9. After 1.5 h., another i.c.v. infusion of NPFF is repeated[1].
References	[1]. Simonin F, et al. RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):466-71. [2]. Wang YQ, et al. Neuropeptide FF receptors antagonist, RF9, attenuates opioid-evoked hypothermia in mice. Peptides. 2008 Jul;29(7):1183-90.

Molecular Formula	C₂₆H₃₈N₆O₃
Molecular Weight	482.62
PSA	200.49000
LogP	4.32590
Storage condition	2-8℃

RF 9 TFA MSDS(Chinese)

1-Adamantanecarbonyl-Arg-Phe-NH2

2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE

2-Adamantanecarbonyl-Arg-Phe-NH2

RF9

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2-ADAMANTANECARBONYL-ARG-PHE-NH2
Price: Click To Check
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GL Biochem (Shanghai) Ltd.
China
Product Name: 2-Adamantanecarbonyl-Arg-Phe-NH2
Price: $Inquiry/1g
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DC Chemicals Limited
China
Product Name: RF-9
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Taiwan Oyi peptide Co. Ltd
China
Product Name: RF 9 TFA
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Delivery: 1 Day
Contact: Vinnie
Email: Jamie@api-made.com

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Price: $242/10mM*1mLinDMSO

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