Delta-12-Prostaglandin J2

Modify Date: 2024-01-13 20:20:42

Delta-12-Prostaglandin J2 Structure
Delta-12-Prostaglandin J2 structure
Common Name Delta-12-Prostaglandin J2
CAS Number 87893-54-7 Molecular Weight 334.450
Density 1.1±0.1 g/cm3 Boiling Point 531.2±50.0 °C at 760 mmHg
Molecular Formula C20H30O4 Melting Point N/A
MSDS N/A Flash Point 289.2±26.6 °C

 Use of Delta-12-Prostaglandin J2


Delta-12-Prostaglandin J2 (Δ12-PGJ2) is a cyclopentenone prostaglandin (PG) with anti-proliferative effect on various tumor cell growth. Delta-12-Prostaglandin J2, a naturally occurring dehydration product of prostaglandin D2, is able to induce apoptosis in HeLa cells via caspase activation[1][2].

 Names

Name 13,14-dihydro-Δ12-prostaglandin J2
Synonym More Synonyms

 Delta-12-Prostaglandin J2 Biological Activity

Description Delta-12-Prostaglandin J2 (Δ12-PGJ2) is a cyclopentenone prostaglandin (PG) with anti-proliferative effect on various tumor cell growth. Delta-12-Prostaglandin J2, a naturally occurring dehydration product of prostaglandin D2, is able to induce apoptosis in HeLa cells via caspase activation[1][2].
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Kim BE, et al. Involvement of Sox-4 in the cytochrome c-dependent AIF-independent apoptotic pathway in HeLa cells induced by Delta12-prostaglandin J2. Exp Mol Med. 2004;36(5):444-453.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 531.2±50.0 °C at 760 mmHg
Molecular Formula C20H30O4
Molecular Weight 334.450
Flash Point 289.2±26.6 °C
Exact Mass 334.214417
PSA 74.60000
LogP 4.12
Vapour Pressure 0.0±3.2 mmHg at 25°C
Index of Refraction 1.558

 Synonyms

12-PROSTAGLANDIN J2
(5Z,12E,15S)-15-Hydroxy-11-oxoprosta-5,9,12-trien-1-oic acid
(5Z,12E,15S)-11-Oxo-15-hydroxyprosta-5,9,12-triene-1-oic acid
DELTA12-PGJ2
Prosta-5,9,12-trien-1-oic acid, 15-hydroxy-11-oxo-, (5Z,12E,15S)-
11-OXO-15S-HYDROXY-PROSTA-5Z,9,12E-TRIEN-1-OIC ACID
13,14-dihydro-Delta(12)-prostaglandin J2
13,14-dihydro-δ(12)-prostaglandin J2
DELTA12-PROSTAGLANDIN J2
9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2
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