60203-57-8

60203-57-8 structure

Name: PGJ2
Chemical Name: prostaglandin J2
CAS Number: 60203-57-8
Molecular Formula: C₂₀H₃₀O₄
Molecular Weight: 334.450
Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
Create Date: 2018-07-03 16:34:19
Modify Date: 2024-01-11 23:19:05
Prostaglandin J2 (PGJ2), an endogenous metabolite of Prostaglandin D2 (PGD2; HY-101988), is a potent PGD2 receptor (DP) agonist with Kis of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC50 value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimer's (AD) and Parkinson's diseases (PD)[1][2][3][4].

Name	prostaglandin J2
Synonyms	(5Z,12ξ,13E,15S)-15-Hydroxy-11-oxoprosta-5,9,13-trien-1-oic acid Prosta-5,9,13-trien-1-oic acid, 15-hydroxy-11-oxo-, (5Z,12ξ,13E,15S)- (5Z,13E,15S)-15-Hydroxy-11-oxoprosta-5,9,13-trien-1-oic acid Prostaglandin J2 PGJ2 Prosta-5,9,13-trien-1-oic acid, 15-hydroxy-11-oxo-, (5Z,13E,15S)- 8-epi-15-J2t-IsoP (Z)-7-[(1S,5R)-5-[(E,3S)-3-hydroxyoct-1-enyl]-4-oxocyclopent-2-en-1-yl]hept-5-enoic acid prostagladin J2

Description	Prostaglandin J2 (PGJ2), an endogenous metabolite of Prostaglandin D2 (PGD2; HY-101988), is a potent PGD2 receptor (DP) agonist with Kis of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC50 value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimer's (AD) and Parkinson's diseases (PD)[1][2][3][4].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Neurological Disease
Target	Human Endogenous Metabolite hDP:0.9 nM (Ki) hCRTH2:6.6 nM (Ki) hEP1:15.678 μM (Ki) hEP2:989 nM (Ki) hEP3:319 nM (Ki) hEP4:1065 nM (Ki) hFP:553 nM (Ki) hIP:>25 μM (Ki) hTP:6426 nM (Ki)
In Vivo	Prostaglandin J2 (PGJ2; 33.4 μg/注射; 单侧注射到 SNpc; 每周一次; 持续 2 或 4 周) 诱导大鼠进行性 PD 样病理，并表现出小胶质细胞和星形胶质细胞激活以及运动缺陷[4]。 Animal Model: Sixteen-week-old Sprague Dawley male rats[4] Dosage: 33.4 μg/injection Administration: Unilateral (right side) injections to the SNpc; once per week for 2 or 4 weeks Result: Induced progressive dopaminergic neuronal loss in the rat substantia nigra pars compacta (SNpc). Developed parkinsonian-like motor deficits in a progressive manner.
References	[1]. D H Wright, et al. Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist. Br J Pharmacol. 1998 Apr;123(7):1317-24. [2]. Nicole Sawyer, et al. Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2. Br J Pharmacol. 2002 Dec;137(8):1163-72. [3]. Maria E Figueiredo-Pereira, et al. Prostaglandin J2: a potential target for halting inflammation-induced neurodegeneration. Ann N Y Acad Sci. 2016 Jan;1363(1):125-37. [4]. Chuhyon Corwin, et al. Prostaglandin D2/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: potential novel therapeutic targets. J Neuroinflammation. 2018 Sep 20;15(1):272.

Density	1.1±0.1 g/cm3
Boiling Point	521.7±50.0 °C at 760 mmHg
Molecular Formula	C₂₀H₃₀O₄
Molecular Weight	334.450
Flash Point	283.4±26.6 °C
Exact Mass	334.214417
PSA	74.60000
LogP	3.34
Vapour Pressure	0.0±3.1 mmHg at 25°C
Index of Refraction	1.555

Hazard Codes	Xn
Risk Phrases	20/21/22-36/37/38
Safety Phrases	26-36

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