Propargyl-PEG3-methane

Modify Date: 2024-01-16 19:08:01

Propargyl-PEG3-methane Structure
Propargyl-PEG3-methane structure
Common Name Propargyl-PEG3-methane
CAS Number 89635-82-5 Molecular Weight 202.24800
Density N/A Boiling Point N/A
Molecular Formula C10H18O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Propargyl-PEG3-methane


Propargyl-PEG3-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 3-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]prop-1-yne
Synonym More Synonyms

 Propargyl-PEG3-methane Biological Activity

Description Propargyl-PEG3-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C10H18O4
Molecular Weight 202.24800
Exact Mass 202.12100
PSA 36.92000
LogP 0.31580

 Synonyms

methoxytriethylenoxy propargyl ether
2,5,8,11-Tetraoxatetradec-13-yne
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