Propargyl-PEG3-OCH2-Boc

Modify Date: 2024-01-02 20:46:06

Propargyl-PEG3-OCH2-Boc Structure
Propargyl-PEG3-OCH2-Boc structure
Common Name Propargyl-PEG3-OCH2-Boc
CAS Number 888010-02-4 Molecular Weight 302.363
Density 1.0±0.1 g/cm3 Boiling Point 365.6±32.0 °C at 760 mmHg
Molecular Formula C15H26O6 Melting Point N/A
MSDS N/A Flash Point 156.1±25.2 °C

 Use of Propargyl-PEG3-OCH2-Boc


Propargyl-PEG3-OCH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Propargyl-PEG4-CH2CO2tBu
Synonym More Synonyms

 Propargyl-PEG3-OCH2-Boc Biological Activity

Description Propargyl-PEG3-OCH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 365.6±32.0 °C at 760 mmHg
Molecular Formula C15H26O6
Molecular Weight 302.363
Flash Point 156.1±25.2 °C
Exact Mass 302.172943
LogP 1.02
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.453

 Synonyms

PROPARGYL-PEG4-CH2COOTBU
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