Biotin-C5-amino-C5-amino

Modify Date: 2024-01-04 20:19:34

Biotin-C5-amino-C5-amino Structure
Biotin-C5-amino-C5-amino structure
Common Name Biotin-C5-amino-C5-amino
CAS Number 89889-51-0 Molecular Weight 470.62600
Density N/A Boiling Point N/A
Molecular Formula C22H38N4O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Biotin-C5-amino-C5-amino


Biotin-C5-amino-C5-amino is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 6-[6-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoylamino]hexanoic acid
Synonym More Synonyms

 Biotin-C5-amino-C5-amino Biological Activity

Description Biotin-C5-amino-C5-amino is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl-Chain

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C22H38N4O5S
Molecular Weight 470.62600
Exact Mass 470.25600
PSA 172.40000
LogP 3.79940
Storage condition 2-8°C

 Synthetic Route

~%

Biotin-C5-amino-C5-amino Structure

Biotin-C5-amino...

CAS#:89889-51-0

Literature: Plaziuk, Damian; Zakrzewski, Janusz; Salmain, Michele; Blauzi, Andrzej; Rychlik, Blaziej; Strzelczyk, Pawel; Bujacz, Anna; Bujacz, Grzegorz Organometallics, 2013 , vol. 32, # 20 p. 5774 - 5783

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

D-biotinylaminohexanoylaminohexanoic acid
D-biotin-Acp-Acp-OH
N-Biotinylcaproylaminocaproic Acid
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