Dextran

Modify Date: 2024-01-02 12:36:21

Dextran Structure
Dextran structure
 Common Name Dextran
CAS Number 9004-54-0 Molecular Weight 504.437
Density 1.8±0.1 g/cm3 Boiling Point 952.8±65.0 °C at 760 mmHg
Molecular Formula C18H32O16 Melting Point -114.22ºC
MSDS Chinese USA Flash Point 327.7±27.8 °C
Symbol GHS08 GHS09
GHS08, GHS09		 Signal Word Warning

 Use of Dextran


Dextran (Dextran 40) has an inhibitory effect on thrombocyte aggregation and coagulation factors and is used as a plasma volume expander.

 Names

Name Hexopyranosyl-(1->6)hexopyranosyl-(1->6)hexose
Synonym More Synonyms

 Dextran Biological Activity

Description Dextran (Dextran 40) has an inhibitory effect on thrombocyte aggregation and coagulation factors and is used as a plasma volume expander.
Related Catalog
References

[1]. Bark BP, et al. Infusion rate and plasma volume expansion of dextran and albumin in the septic guinea pig. Acta Anaesthesiol Scand. 2014 Jan;58(1):44-51.

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Boiling Point 952.8±65.0 °C at 760 mmHg
Melting Point -114.22ºC
Molecular Formula C18H32O16
Molecular Weight 504.437
Flash Point 327.7±27.8 °C
Exact Mass 504.169037
PSA 276.52000
LogP -4.26
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.652

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HH9247500
CHEMICAL NAME :
Dextran 70
CAS REGISTRY NUMBER :
9004-54-0
LAST UPDATED :
199701

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
6 mg/kg
TOXIC EFFECTS :
Cardiac - other changes Vascular - other changes Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 2,1502,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 6,1023,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 6,1023,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 6,1023,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>12 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 6,1023,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
13900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 6,1023,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
12100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 6,1023,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
17400 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 6,1023,1972 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
900 mL/kg/30D-C
TOXIC EFFECTS :
Liver - changes in liver weight Endocrine - changes in adrenal weight Blood - normocytic anemia
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 6,1089,1972
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
4680 mL/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight Blood - normocytic anemia Related to Chronic Data - death
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 6,1103,1972
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
3120 mL/kg/26W-I
TOXIC EFFECTS :
Liver - changes in liver weight Blood - normocytic anemia Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 3,369,1975
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
3120 mL/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight Blood - normocytic anemia Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 3,369,1975 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
675 gm/kg
SEX/DURATION :
female 8-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 6,1119,1972
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
3640 gm/kg
SEX/DURATION :
male 91 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 3,369,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83342 No. of Facilities: 86 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 369 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83342 No. of Facilities: 432 (estimated) No. of Industries: 3 No. of Occupations: 6 No. of Employees: 7612 (estimated) No. of Female Employees: 4671 (estimated)

 Safety Information

Symbol GHS08 GHS09
GHS08, GHS09
Signal Word Warning
Hazard Statements H373-H411
Precautionary Statements P273
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn,Xi
Risk Phrases R20/21/22
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS HH9230000
HS Code 2932999099

 Synthetic Route

sucrose structure

sucrose

CAS#:57-50-1

~%

Dextran Structure

Dextran

CAS#:9004-54-0

Literature: Carbohydrate Research, , vol. 346, # 9 p. 1077 - 1082
sucrose structure

sucrose

CAS#:57-50-1

~%

D-(+)-Glucose structure

D-(+)-Glucose

CAS#:50-99-7

d-leucrose structure

d-leucrose

CAS#:7158-70-5

Dextran Structure

Dextran

CAS#:9004-54-0

Literature: Journal of Agricultural and Food Chemistry, , vol. 59, # 8 p. 4148 - 4155
Cellobiose structure

Cellobiose

CAS#:133-99-3

sucrose structure

sucrose

CAS#:57-50-1

~%

α-D-Glcp-(1->6)-α-D-Glcp-(1->4)-D-Glcp structure

α-D-Glcp-(1->6)...

CAS#:490-40-4

Dextran Structure

Dextran

CAS#:9004-54-0

Literature: Carbohydrate Research, , vol. 320, # 3-4 p. 183 - 191
sucrose structure

sucrose

CAS#:57-50-1

~%

D-glucopyranose structure

D-glucopyranose

CAS#:2280-44-6

D-Fructopyranose structure

D-Fructopyranose

CAS#:6347-01-9

Dextran Structure

Dextran

CAS#:9004-54-0

Literature: Carbohydrate Research, , vol. 320, # 3-4 p. 183 - 191

 Precursor & DownStream

Precursor  2

DownStream  0

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles154

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 Synonyms

(+)-2-propano
MFCD00130935
R(+)-PROPRANOLOL HYDROCHLORIDE &(r)-2-propano
dexpropranolol
Dextran T-40
2r-propranolol
R(+)-PROPRANOLOL HCL
α-D-Glucopyranosyl-(1->6)-α-D-glucopyranosyl-(1->6)-D-glucose
(+)-propranolol
D(+)-propranolol
R-(+)-propranolol
pine pollen
dextropropranolol
Dextran T2000
D-Glucose, O-α-D-glucopyranosyl-(1->;6)-O-α-D-glucopyranosyl-(1->6)-
Dextran
EINECS 232-677-5
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