Hydroxypropyl Cellulose

Modify Date: 2024-01-02 18:24:09

Hydroxypropyl Cellulose Structure
Hydroxypropyl Cellulose structure
Common Name Hydroxypropyl Cellulose
CAS Number 9004-64-2 Molecular Weight 806.930
Density 1.3±0.1 g/cm3 Boiling Point 891.2±65.0 °C at 760 mmHg
Molecular Formula C36H70O19 Melting Point N/A
MSDS Chinese USA Flash Point 492.8±34.3 °C

 Use of Hydroxypropyl Cellulose


Hydroxypropyl Cellulose is somewhat amphiphilic in character and is a surfactant. Hydroxypropyl Cellulose can be used as a pharmaceutical excipient, such as coating agent, emulsifier, suspension, tablet, thickener, viscosifier. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].

 Names

Name Hydroxypropyl cellulose
Synonym More Synonyms

 Hydroxypropyl Cellulose Biological Activity

Description Hydroxypropyl Cellulose is somewhat amphiphilic in character and is a surfactant. Hydroxypropyl Cellulose can be used as a pharmaceutical excipient, such as coating agent, emulsifier, suspension, tablet, thickener, viscosifier. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].
Related Catalog
References

[1]. Werbowyj R S, et al. Liquid crystalline structure in aqueous hydroxypropyl cellulose solutions[J]. Molecular Crystals and Liquid Crystals, 1976, 34(4): 97-103.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.  

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 891.2±65.0 °C at 760 mmHg
Molecular Formula C36H70O19
Molecular Weight 806.930
Flash Point 492.8±34.3 °C
Exact Mass 806.451111
LogP -1.24
Appearance of Characters powder | White to light cream
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.532
Stability Stable. Incompatible with strong oxidizing agents. Combustible.
Water Solubility polar oganic solvents: soluble

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes S24/S25
Safety Phrases 24/25
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS NF9050000

 Articles30

More Articles
Polymer-directed crystallization of atorvastatin.

J. Pharm. Sci. 101(8) , 2941-51, (2012)

Living organisms secrete minerals composed of peptides and proteins, resulting in "mesocrystals" of three-dimensional-assembled composite structures. Recently, this biomimetic polymer-directed crystal...

Stabilization of fenofibrate in low molecular weight hydroxypropylcellulose matrices produced by hot-melt extrusion.

Drug Dev. Ind. Pharm. 39(2) , 290-8, (2013)

The objective of this study was to improve the dissolution rate and to enhance the stability of a poorly water-soluble and low glass-trasition temperature (T(g)) model drug, fenofibrate, in low molecu...

Improved supersaturation and oral absorption of dutasteride by amorphous solid dispersions.

Chem. Pharm. Bull. 60(11) , 1468-73, (2012)

In this study, amorphous solid dispersions containing dutasteride and various excipients, manufactured by spray-drying processes, were characterized to determine the effects on their ability to form s...

 Synonyms

β-D-Glucopyranoside, 2-hydroxypropyl 2,3,6-tris-O-(2-hydroxypropyl)-4-O-[2,3,4,6-tetrakis-O-(2-hydroxypropyl)-α-D-glucopyranosyl]-
Klucel
MFCD00132688
2-Hydroxypropyl 2,3,6-tris-O-(2-hydroxypropyl)-4-O-[2,3,4,6-tetrakis-O-(2-hydroxypropyl)-α-D-glucopyranosyl]-β-D-glucopyranoside
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