Globosuxanthone A

Modify Date: 2024-01-05 15:36:33

Globosuxanthone A Structure
Globosuxanthone A structure
 Common Name Globosuxanthone A
CAS Number 917091-74-8 Molecular Weight 304.252
Density 1.6±0.1 g/cm3 Boiling Point 506.8±50.0 °C at 760 mmHg
Molecular Formula C15H12O7 Melting Point N/A
MSDS N/A Flash Point 192.9±23.6 °C

 Use of Globosuxanthone A


Globosuxanthone A is a dihydroxanthenone with obvious antifungal activity towards Fusarium graminearum, Fusarium solani, and Botrytis cinerea with MIC values of 4, 8, and 16 μg/mL, respectively. Anticancer activity[1][2].

 Names

Name Globosuxanthone A
Synonym More Synonyms

 Globosuxanthone A Biological Activity

Description Globosuxanthone A is a dihydroxanthenone with obvious antifungal activity towards Fusarium graminearum, Fusarium solani, and Botrytis cinerea with MIC values of 4, 8, and 16 μg/mL, respectively. Anticancer activity[1][2].
Related Catalog
In Vitro Globosuxanthone A shows cytotoxicities against NCI-H460, MCF-7, SF-268, PC-3, PC-3M, LNCaP, DU-145 cells (IC50=0.65-3.6 µM)[1]. Globosuxanthone A impairs cell cycle progression of NCI-H460 and PC-3M cells leading to accumulation in the G2/M and S phases [1].
References

[1]. Miao C, et al. Antifungal xanthones produced by the endophytic fungus Paraconionthyrium sp. YM 311593. Folia Microbiol (Praha). 2020;65(3):567-572.

[2]. Wijeratne EM, et al. A new dihydroxanthenone from a plant-associated strain of the fungus Chaetomium globosum demonstrates anticancer activity. Bioorg Med Chem. 2006;14(23):7917-7923.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 506.8±50.0 °C at 760 mmHg
Molecular Formula C15H12O7
Molecular Weight 304.252
Flash Point 192.9±23.6 °C
Exact Mass 304.058289
LogP 2.20
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.704

 Synonyms

globosuxanthone A
Methyl (1R,2R)-1,2,8-trihydroxy-9-oxo-2,9-dihydro-1H-xanthene-1-carboxylate
1H-Xanthene-1-carboxylic acid, 2,9-dihydro-1,2,8-trihydroxy-9-oxo-, methyl ester, (1R,2R)-
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