Proflavine

Modify Date: 2024-01-06 11:13:58

Proflavine structure	Common Name	Proflavine
	CAS Number	92-62-6	Molecular Weight	209.24700
	Density	1.346 g/cm3	Boiling Point	506.9ºC at 760 mmHg
	Molecular Formula	C₁₃H₁₁N₃	Melting Point	260ºC
	MSDS	N/A	Flash Point	292.9ºC

Use of Proflavine

Proflavine, an acridine dye, is a known DNA intercalating agent. Anti-microbial agent[1]. Proflavine behaves as a pore blocker for Kir3.2. Proflavine is a potential lead compound for Kir3.2-associated neurological diseases[2].

Name	3,6-diaminoacridine
Synonym	More Synonyms

Description	Proflavine, an acridine dye, is a known DNA intercalating agent. Anti-microbial agent[1]. Proflavine behaves as a pore blocker for Kir3.2. Proflavine is a potential lead compound for Kir3.2-associated neurological diseases[2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Mansour K.Gatasheh, et al. Proflavine an acridine DNA intercalating agent and strong antimicrobial possessing potential properties of carcinogen. Karbala International Journal of Modern Science. 2017 Dec, 3(4): 272-278. [2]. Hitoshi Kawada, et al. Isolation of proflavine as a blocker of G protein-gated inward rectifier potassium channels by a cell growth-based screening system. Neuropharmacology. 2016 Oct;109:18-28. [3]. Jiaxin Chen, et al. Determination of proflavine in rat whole blood without sample pretreatment by laser desorption postionization mass spectrometry. Anal Bioanal Chem. 2017 Apr;409(11):2813-2819.

Description

Related Catalog

Research Areas >> Neurological Disease

Signaling Pathways >> Anti-infection >> Bacterial

References

[1]. Mansour K.Gatasheh, et al. Proflavine an acridine DNA intercalating agent and strong antimicrobial possessing potential properties of carcinogen. Karbala International Journal of Modern Science. 2017 Dec, 3(4): 272-278.

[2]. Hitoshi Kawada, et al. Isolation of proflavine as a blocker of G protein-gated inward rectifier potassium channels by a cell growth-based screening system. Neuropharmacology. 2016 Oct;109:18-28.

[3]. Jiaxin Chen, et al. Determination of proflavine in rat whole blood without sample pretreatment by laser desorption postionization mass spectrometry. Anal Bioanal Chem. 2017 Apr;409(11):2813-2819.

Density	1.346 g/cm3
Boiling Point	506.9ºC at 760 mmHg
Melting Point	260ºC
Molecular Formula	C₁₃H₁₁N₃
Molecular Weight	209.24700
Flash Point	292.9ºC
Exact Mass	209.09500
PSA	64.93000
LogP	3.71480
Index of Refraction	1.833

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR8670000

CHEMICAL NAME :: Acridine, 3,6-diamino-

CAS REGISTRY NUMBER :: 92-62-6

BEILSTEIN REFERENCE NO. :: 0166050

LAST UPDATED :: 199806

DATA ITEMS CITED :: 42

MOLECULAR FORMULA :: C13-H11-N3

MOLECULAR WEIGHT :: 209.27

WISWESSER LINE NOTATION :: T C666 BNJ EZ MZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 11111 ug/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 13500 nmol/L

REFERENCE :: ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75, 1903-71. For publisher information, see JCROD7. Volume(issue)/page/year: 67,127,1965 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 24,195,1980 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 24,195,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6466 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 628 (estimated) No. of Female Employees: 621 (estimated)

HS Code	2933990090

Precursor 8
CAS#:952-23-8 Proflavine hydr... CAS#:26946-33-8 Benzenamine,4,4... CAS#:108-45-2 m-Phenylenediamine CAS#:101-22-4 N,N'-bis(3-amin...
CAS#:42832-87-1 3,6-Diamino-9(1... CAS#:101-77-9 4,4′-methylened... CAS#:56-81-5 Glycerol CAS#:144-62-7 Oxalic acid
DownStream 7
CAS#:15724-70-6 Acetamide,N,N'-... CAS#:113110-49-9 N-[6-[(4-methyl... CAS#:74165-99-4 N-(6-aminoacrid... CAS#:103900-67-0 3,6-dihydroxy-4...
CAS#:43129-74-4 6-hydroxy-10H-a... CAS#:581-29-3 acridin-3-ylamine CAS#:63676-40-4 3,6-diisothiocy...

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

3,6-Diamino-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile

3,6-Diamino-5-cyan-1-methyl-1H-pyrazolo<3,4-b>pyridin

acridine-3,6-diamine

3,6-Acridinediamine

Shanghai Nianxing Industrial Co., Ltd
China
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ShangHai DC Chemicals Co.,Ltd
China
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DC Chemicals Limited
China
Product Name: Proflavine;3,6-Diaminoacridine
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China
Product Name: proflavine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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