Fosphenytoin (disodium)
Modify Date: 2024-01-02 19:01:33
Fosphenytoin (disodium) structure
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Common Name | Fosphenytoin (disodium) | ||
|---|---|---|---|---|
| CAS Number | 92134-98-0 | Molecular Weight | 406.23800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H13N2Na2O6P | Melting Point | 220ºC | |
| MSDS | N/A | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of Fosphenytoin (disodium)Fosphenytoin sodium is a phenytoin prodrug with similar anticonvulsant properties. |
| Name | disodium,(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl phosphate |
|---|---|
| Synonym | More Synonyms |
| Description | Fosphenytoin sodium is a phenytoin prodrug with similar anticonvulsant properties. |
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| Related Catalog | |
| In Vivo | Fosphenytoin is an effective neuroprotectant against ischemia-induced damage. In fosphenytoin (30 mg/kg, i.m.)-treated rat 5 min after ischemia episode, hippocampal CA1 pyramidal neurons remain at near control level (13.90 +/- 0.92), however, GFAP staining iss not significantly changed[1]. In fosphenytoin (84 mg/kg)-treated rat, the relative bioavailability of fosphenytoin is 83%. In fully kindled female Wistar rats, fosphenytoin dose-dependently increases the focal seizure (afterdischarge) threshold. Seizure severity and duration at threshold are reduced only after the highest does of fosphenytoin tested (84 mg/kg)[2]. |
| Animal Admin | A total of four groups of rats, including normal (n=2), sham operated (n=2), ischemia with saline-treated (n=2), and ischemia with fosphenytoin-treated (n=2), are studied. Postischemic rats in saline-treated and fosphenytoin-treated groups receive a single i.m. injection of saline or fosphenytoin (30 mg/kg), respectively, in the right hind limb 5 minutes after resuscitation. Sham-operated animals are treated similarly except for chest compression. All rats are killed on the 7th postischemic day by decapitation. Brains are immediately removed, bisected longitudinally, and immersed in 4% buffered neutral formaldehyde containing 0.25% glutaraldehyde for a minimum of 2 days at 4°C. Portions of the brain containing the dorsal hippocampus are coronally sectioned with a vibratome at 40 μm. With the aid of a dissecting microscope, rectangular blocks of about 1 mm2 in size encompassing the mid-CA1 region from sections that approximate Bregma -3.6 are dissected, postfixed in 2% osmium tetroxide, and dehydrated in ascending concentrations of ethanol before being embedded in Araldite 502. Sections of polymerized blocks 1 μm thick are cut and toluidine blue stained for light microscopic examination. |
| References |
| Melting Point | 220ºC |
|---|---|
| Molecular Formula | C16H13N2Na2O6P |
| Molecular Weight | 406.23800 |
| Exact Mass | 406.03100 |
| PSA | 131.64000 |
| LogP | 2.69190 |
| Storage condition | 2-8°C |
| Water Solubility | H2O: ≥15mg/mL |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | Missing Phrase - N15.00950417 |
| Hazard Codes | T |
| Risk Phrases | 45-61-22 |
| Safety Phrases | 53-36/37-45 |
| RIDADR | UN 2811 6.1 / PGIII |
| HS Code | 2933790090 |
| HS Code | 2933790090 |
|---|---|
| Summary | 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0% |
| Pro-Epanutin |
| ACC 9653-010 |
| ACC 9653 |
| Fosphenytoin disodium salt |
| CI 982 |
| Cerebyx |
| Fosphenytoin sodium |
| Fosphenytoin (disodium) |