5-Hydroxyuridine

Modify Date: 2024-01-10 18:43:32

5-Hydroxyuridine Structure
5-Hydroxyuridine structure
Common Name 5-Hydroxyuridine
CAS Number 957-77-7 Molecular Weight 260.20
Density 1.8±0.1 g/cm3 Boiling Point N/A
Molecular Formula C9H12N2O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 5-Hydroxyuridine


5-Hydroxyuridine (OHUrd) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 5-hydroxyuridine
Synonym More Synonyms

 5-Hydroxyuridine Biological Activity

Description 5-Hydroxyuridine (OHUrd) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Molecular Formula C9H12N2O7
Molecular Weight 260.20
Exact Mass 260.064453
PSA 145.01000
LogP -1.51
Index of Refraction 1.698
Storage condition 2-8°C

 Synonyms

5-Hydroxy-uridin
5-Hydroxy-uracil-ribotid
Uridine, 5-hydroxy-
Uridine,5-hydroxy
5-hydroxy-uridine
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]-5-hydroxy-pyrimidine-2,4-quinone
5-Hydroxyuridine
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxy-pyrimidine-2,4-dione