Rv1625c agonist V-59
Modify Date: 2024-01-19 10:27:04
Rv1625c agonist V-59 structure
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Common Name | Rv1625c agonist V-59 | ||
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| CAS Number | 958588-17-5 | Molecular Weight | 371.376 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H18FN7O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Rv1625c agonist V-59Rv1625c agonist V-59 (V-59) is a specific small molecule agonist of the Mtb adenylyl cyclase Rv1625c, inhibits Mtb growth in macrophages (EC50=0.3 uM) in an Rv1625c-dependent mechanism.V-59 inhibits Mtb growth in cholesterol media (EC50 0.70 uM), but not in media containing the two-carbon fatty acid acetate, or in standard rich growth media.V-59 stimulates Rv1625c to produce cAMP, which is necessary for V-59 to inhibit Mtb growth.Chemically activating Rv1625c via V-59 preferentially inhibits cholesterol utilization in WT Mtb, rather than equally inhibiting all lipid utilization by the bacterium. |
| Name | Rv1625c agonist V-59 |
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| Description | Rv1625c agonist V-59 (V-59) is a specific small molecule agonist of the Mtb adenylyl cyclase Rv1625c, inhibits Mtb growth in macrophages (EC50=0.3 uM) in an Rv1625c-dependent mechanism.V-59 inhibits Mtb growth in cholesterol media (EC50 0.70 uM), but not in media containing the two-carbon fatty acid acetate, or in standard rich growth media.V-59 stimulates Rv1625c to produce cAMP, which is necessary for V-59 to inhibit Mtb growth.Chemically activating Rv1625c via V-59 preferentially inhibits cholesterol utilization in WT Mtb, rather than equally inhibiting all lipid utilization by the bacterium. |
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| References | 1. Kaley M Wilburn, et al. PLoS Pathog. 2022 Feb 8;18(2):e1009862. |
| Molecular Formula | C17H18FN7O2 |
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| Molecular Weight | 371.376 |