1,3-Bis-aminooxy propane

Modify Date: 2024-01-12 18:45:24

1,3-Bis-aminooxy propane structure	Common Name	1,3-Bis-aminooxy propane
	CAS Number	98627-69-1	Molecular Weight	106.12400
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃H₁₀N₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 1,3-Bis-aminooxy propane

1,3-Bis-aminooxy propane is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	O-(3-aminooxypropyl)hydroxylamine
Synonym	More Synonyms

Description	1,3-Bis-aminooxy propane is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl-Chain
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

N/A

CAS#:94212-54-1

1,3-Bis-aminoox...

CAS#:98627-69-1

Literature: Bauer,L.; Suresh,K.S. Journal of Organic Chemistry, 1963 , vol. 28, p. 1604 - 1608

N-Hydroxyphthalimide

CAS#:524-38-9

DBU

CAS#:6674-22-2

1,3-Dibromopropane

CAS#:109-64-8

N/A

CAS#:94212-54-1

Detail

Literature: Novo Nordisk A/S Patent: US2011/306551 A1, 2011 ;

Precursor 3
CAS#:524-38-9 N-Hydroxyphthalimide CAS#:6674-22-2 DBU CAS#:109-64-8 1,3-Dibromopropane
DownStream 0

hydroxylamine-O-[3-(aminooxy)propyl]

1,3-diaminoxypropane

1.3-Bis-aminooxy-propan

1,3-bis-aminooxy-propane

O,O'-propane-1,3-diyl-bis-hydroxylamine

Hydroxylamine,O,O'-1,3-propanediylbis