β2AR/M-receptor agonist-2

Modify Date: 2024-01-03 08:00:30

β2AR/M-receptor agonist-2 structure	Common Name	β2AR/M-receptor agonist-2
	CAS Number	1017857-38-3	Molecular Weight	717.31
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₆H₄₉ClN₄O₇S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of β2AR/M-receptor agonist-2

β2AR/M-receptor agonist-2 (compound 15) is a muscarinic antagonist and β2 adrenoceptor agonist (MABA). β2AR/M-receptor agonist-2 shows potency to β2 adrenoceptor with an EC50 value of 3.7 nM. β2AR/M-receptor agonist-2 also has potency to human cloned M3 receptor with a Ki value of 0.73 nM. β2AR/M-receptor agonist-2 is a potent bronchodilator, it can be used for the research of chronic obstructive pulmonary disease (COPD)[1].

Name	β2AR/M-receptor agonist-2

Description	β2AR/M-receptor agonist-2 (compound 15) is a muscarinic antagonist and β2 adrenoceptor agonist (MABA). β2AR/M-receptor agonist-2 shows potency to β2 adrenoceptor with an EC50 value of 3.7 nM. β2AR/M-receptor agonist-2 also has potency to human cloned M3 receptor with a Ki value of 0.73 nM. β2AR/M-receptor agonist-2 is a potent bronchodilator, it can be used for the research of chronic obstructive pulmonary disease (COPD)[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Inflammation/Immunology
In Vivo	β2AR/M-receptor agonist-2 剂量依赖地抑制甲基胆碱诱导的犬支气管收缩，其 ID50 值为 50 mg[1]。
References	[1]. Laura Hilton, et al. Optimized glucuronidation of dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD. MedChemComm. 2011.

Molecular Formula	C₃₆H₄₉ClN₄O₇S
Molecular Weight	717.31

β2AR/M-receptor agonist-2

Use of β2AR/M-receptor agonist-2

Names

β2AR/M-receptor agonist-2 Biological Activity

Chemical & Physical Properties