ROS 234 dioxalate

Modify Date: 2022-01-20 20:20:28

ROS 234 dioxalate structure	Common Name	ROS 234 dioxalate
	CAS Number	1781941-93-2	Molecular Weight	421.36
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₉N₅O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ROS 234 dioxalate

ROS 234 dioxalate is a potent H3 antagonist, with a pKB of 9.46 for Guinea-pig ileum H3-receptor, a pKi of 8.90 for Rat cerebral cortex H3-receptor, and a ED50 of 19.12 mg/kg (ip) in ex vivo of Rat cerebral cortex. ROS 234 dioxalate diaplays poor central access[1][2].

Name	ROS 234 dioxalate

Description	ROS 234 dioxalate is a potent H3 antagonist, with a pKB of 9.46 for Guinea-pig ileum H3-receptor, a pKi of 8.90 for Rat cerebral cortex H3-receptor, and a ED50 of 19.12 mg/kg (ip) in ex vivo of Rat cerebral cortex. ROS 234 dioxalate diaplays poor central access[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	H2 Receptor:8.90 (pKi, Rat cerebral cortex H3-receptor)
In Vivo	ROS 234, centrally injected, significantly shortens pentobarbital narcosis[1].
References	[1]. Ballabeni V, et al. CNS access of selected H3-antagonists: ex vivo binding study in rats. Inflamm Res. 2002 Apr;51 Suppl 1:S55-6. [2]. Mor M, et al. Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H3-antagonists. Bioorg Med Chem. 2004 Feb 15;12(4):663-74.

Molecular Formula	C₁₇H₁₉N₅O₈
Molecular Weight	421.36

ROS 234 dioxalate

Use of ROS 234 dioxalate

Names

ROS 234 dioxalate Biological Activity

Chemical & Physical Properties