Influenza virus-IN-4

Modify Date: 2024-01-02 12:58:02

Influenza virus-IN-4 structure	Common Name	Influenza virus-IN-4
	CAS Number	2133818-85-4	Molecular Weight	418.50
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₃₁FN₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Influenza virus-IN-4

Influenza virus-IN-4 (compound 11e) is a potent influenza virus neuraminidase inhibitor with IC50s of 3.4, 0.094, 0.79, 0.077 µM for H5N1, H5N2, H5N6, H5N8, respectively. Influenza virus-IN-4 shows NA (neuraminidase enzyme)-inhibitory activity. Influenza virus-IN-4 shows low cytotoxicity with an CC50 of >200 µM. Influenza virus-IN-4 shows no obvious toxicity at the dose of 1500 mg/kg in mice[1].

Name	Influenza virus-IN-4

Description	Influenza virus-IN-4 (compound 11e) is a potent influenza virus neuraminidase inhibitor with IC50s of 3.4, 0.094, 0.79, 0.077 µM for H5N1, H5N2, H5N6, H5N8, respectively. Influenza virus-IN-4 shows NA (neuraminidase enzyme)-inhibitory activity. Influenza virus-IN-4 shows low cytotoxicity with an CC50 of >200 µM. Influenza virus-IN-4 shows no obvious toxicity at the dose of 1500 mg/kg in mice[1].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Inflammation/Immunology
Target	IC50: 3.4 µM (H5N1); 0.094 µM (H5N2); 0.79 µM (H5N6); 0.077 µM (H5N8)[1]
In Vitro	Influenza virus-IN-4 (compound 11e) shows NA (neuraminidase enzyme)-inhibitory activity with IC50s of 33.26, 16.81, 45.46, 33.02, 5270.33, 0.00043, 0.00347 nM for H5N1, H5N2, H5N6, H5N8, H5N1eH274Y, N1 (H1N1pdm09) and N2 (H3N2), respectively[1].
References	[1]. Ai W, et al. Discovery of novel "Dual-site" binding oseltamivir derivatives as potent influenza virus neuraminidase inhibitors. Eur J Med Chem. 2020 Apr 1;191:112147.

Molecular Formula	C₂₃H₃₁FN₂O₄
Molecular Weight	418.50

Influenza virus-IN-4

Use of Influenza virus-IN-4

Names

Influenza virus-IN-4 Biological Activity

Chemical & Physical Properties