γ-Secretase modulator 12

Modify Date: 2024-01-07 11:01:02

γ-Secretase modulator 12 structure	Common Name	γ-Secretase modulator 12
	CAS Number	2204249-82-9	Molecular Weight	397.47
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₃N₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of γ-Secretase modulator 12

γ-Secretase modulator 12 (Compound 1a) is a γ-secretase modulator that can selectively decrease amyloid-β42 (Aβ42) levels (IC50 of 0.39 µM). γ-Secretase modulator 12 can be used for Alzheimer’s disease research. γ-Secretase modulator 12 has a good brain/plasma ratio (Kp, brain = 0.72) in mice[1].

Name	γ-Secretase modulator 12

Description	γ-Secretase modulator 12 (Compound 1a) is a γ-secretase modulator that can selectively decrease amyloid-β42 (Aβ42) levels (IC50 of 0.39 µM). γ-Secretase modulator 12 can be used for Alzheimer’s disease research. γ-Secretase modulator 12 has a good brain/plasma ratio (Kp, brain = 0.72) in mice[1].
Related Catalog	Research Areas >> Neurological Disease
References	[1]. Ryuichi Sekioka, et al. Discovery of N-ethylpyridine-2-carboxamide derivatives as a novel scaffold for orally active γ-secretase modulators. Bioorg Med Chem. 2020 Jan 1;28(1):115132.

Molecular Formula	C₂₅H₂₃N₃O₂
Molecular Weight	397.47

γ-Secretase modulator 12

Use of γ-Secretase modulator 12

Names

γ-Secretase modulator 12 Biological Activity

Chemical & Physical Properties