JNK3 inhibitor-2

Modify Date: 2024-04-09 19:36:47

JNK3 inhibitor-2 Structure
JNK3 inhibitor-2 structure
Common Name JNK3 inhibitor-2
CAS Number 2366264-18-6 Molecular Weight 314.34
Density N/A Boiling Point N/A
Molecular Formula C20H14N2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of JNK3 inhibitor-2


JNK3 inhibitor-2 is a potent and selective JNK3 inhibitor with IC50 values of >100, >100, 0.25 µM for JNK1, JNK2, JNK3, respectively. JNK3 inhibitor-2 shows DDR1 and EGFR (T790M, L858R) inhibition[1].

 Names

Name JNK3 inhibitor-2

 JNK3 inhibitor-2 Biological Activity

Description JNK3 inhibitor-2 is a potent and selective JNK3 inhibitor with IC50 values of >100, >100, 0.25 µM for JNK1, JNK2, JNK3, respectively. JNK3 inhibitor-2 shows DDR1 and EGFR (T790M, L858R) inhibition[1].
Related Catalog
Target

JNK1:>100 μM (IC50)

JNK2:>100 μM (IC50)

JNK3:0.25 μM (IC50)

In Vitro JNK3 inhibitor-2 (compound J46) shows 30% and 60% inhibition to JNK2α2 at 30 μM and 100 μM, respectively[1]. JNK3 inhibitor-2 shows inhibitory ability for DDR1 and EGFR (T790M, L858R) with IC50s of 0.16, 0.37 µM, respectively[1].
References

[1]. Dou X, et al. Rational modification, synthesis and biological evaluation of 3,4-dihydroquinoxalin-2(1H)-one derivatives as potent and selective c-Jun N-terminal kinase 3 (JNK3) inhibitors. Eur J Med Chem. 2020 Sep 1;201:112445.

 Chemical & Physical Properties

Molecular Formula C20H14N2O2
Molecular Weight 314.34