Tubulin polymerization-IN-25
Modify Date: 2024-01-25 22:50:40
Tubulin polymerization-IN-25 structure
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Common Name | Tubulin polymerization-IN-25 | ||
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| CAS Number | 2490538-46-8 | Molecular Weight | 414.48 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H18N2O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Tubulin polymerization-IN-25Tubulin polymerization-IN-25 (compound 17f) is a dual inhibitor of tubulin polymerization and farnesyl transferase (FTase) with IC50s of 1.11 μM and 0.39 μM, respectively. Tubulin polymerization-IN-25 displays cytotoxicity and excellent antitumor activity [1]. |
| Name | Tubulin polymerization-IN-25 |
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| Description | Tubulin polymerization-IN-25 (compound 17f) is a dual inhibitor of tubulin polymerization and farnesyl transferase (FTase) with IC50s of 1.11 μM and 0.39 μM, respectively. Tubulin polymerization-IN-25 displays cytotoxicity and excellent antitumor activity [1]. |
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| Related Catalog | |
| Target |
IC50: 1.11 μM (Tubulin); 0.39 μM (FTase)[1] |
| In Vitro | Tubulin polymerization-IN-25 (compound 17f) is a dual inhibitor (MTI-FTI hybrids) acting on tubulin polymerization and on FTase[1]. Tubulin polymerization-IN-25 (10 μM, 48 h) inhibits cells growth and induces cell cytotoxicity on multiple cancer cell lines[1]. Cell Viability Assay[1] Cell Line: Leukemia cells: SR, CCRF-CEM, K-562; lung cancer cell CCRF-CEMNCI-H522; melanoma cell M14 Concentration: 10 μM Incubation Time: 48 hours Result: Inhibited cell growth. Cell Cytotoxicity Assay[1] Cell Line: NCI-H522 (lung cancer), COLO-205 and HT29 (colon cancer), SF-539 (human glioblastoma), MDA-MB-435 (melanoma), OVCAR-3 (ovarian cancer) and A498 (renal cancer) Concentration: 10 μM Incubation Time: 48 hours Result: Induced cell cytotoxicity. |
| References |
| Molecular Formula | C24H18N2O3S |
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| Molecular Weight | 414.48 |