Tempol-d17,15N

Modify Date: 2024-01-10 09:42:56

Tempol-d17,15N structure	Common Name	Tempol-d17,15N
	CAS Number	90429-66-6	Molecular Weight	190.34300
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₉HD₁₇NO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Tempol-d17,15N

Tempol-d17,15N is the deuterium labeled Tempol[1]. Tempol is a general superoxide dismutase (SOD)-mimetic drug that efficiently neutralizes reactive oxygen species (ROS)[2][3].

Name	4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (d17, 15n)

Description	Tempol-d17,15N is the deuterium labeled Tempol[1]. Tempol is a general superoxide dismutase (SOD)-mimetic drug that efficiently neutralizes reactive oxygen species (ROS)[2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Vilar-Pereira G, et al. Resveratrol Reverses Functional Chagas Heart Disease in Mice. PLoS Pathog. 2016 Oct 27;12(10):e1005947. [3]. Chatterjee PK, et al. Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat. Kidney Int. 2000 Aug58(2):658-73.

Molecular Formula	C₉HD₁₇NO₂
Molecular Weight	190.34300
Exact Mass	190.23700
PSA	23.47000
LogP	1.28370