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N-乙酰基色胺

N-乙酰基色胺用途

N-乙酰色胺是视网膜褪黑素受体的部分激动剂[1]。N-乙酰色胺也用于测定5-羟色胺N-乙酰转移酶活性[2]。

N-乙酰基色胺名称

[ CAS 号 ]:
1016-47-3

[ 中文名 ]:
N-乙酰基色胺

[ 英文名 ]:
N-Acetyltryptamine

[英文别名 ]:

N-[2-(1H-indol-3-yl)ethyl]acetamide
Tocris-0357
Chicago Sky Blue 6B
N-Acetyltryptamine
N-(2-(1H-Indol-3-yl)ethyl)acetamide

N-乙酰基色胺生物活性

[ 描述 ]:

N-乙酰色胺是视网膜褪黑素受体的部分激动剂[1]。N-乙酰色胺也用于测定5-羟色胺N-乙酰转移酶活性[2]。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> 褪黑激素受体

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 褪黑激素受体

研究领域 >> 神经疾病

[参考文献]

[1]. Sugden D, et al. Melatonin receptor pharmacology: toward subtype specificity. Biol Cell. 1997 Nov;89(8):531-7.

[2]. De Angelis J, et al. Kinetic analysis of the catalytic mechanism of serotonin N-acetyltransferase (EC 2.3.1.87). J Biol Chem. 1998 Jan 30;273(5):3045-50.

N-乙酰基色胺物理化学性质

[ 密度 ]:
1.164 g/cm3

[ 沸点 ]:
484.7ºC at 760 mmHg

[ 分子式 ]:
C₁₂H₁₄N₂O

[ 分子量 ]:
202.25200

[ 闪点 ]:
246.9ºC

[ 精确质量 ]:
202.11100

[ PSA ]:
44.89000

[ LogP ]:
2.23740

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
1.51E-09mmHg at 25°C

[ 折射率 ]:
1.619

[ 储存条件 ]:
室温，干燥

N-乙酰基色胺MSDS

N-乙酰基色胺安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933990090

N-乙酰基色胺合成路线

N-乙酰基色胺上下游产品

N-乙酰基色胺上游产品

N-乙酰基色胺下游产品

N-乙酰基色胺海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

N-乙酰基色胺文献

Chloroplastic and cytoplasmic overexpression of sheep serotonin N-acetyltransferase in transgenic rice plants is associated with low melatonin production despite high enzyme activity.

J. Pineal Res. 58(4) , 461-9, (2015)

Serotonin N-acetyltransferase (SNAT), the penultimate enzyme in melatonin biosynthesis, catalyzes the conversion of serotonin into N-acetylserotonin. Plant SNAT is localized in chloroplasts. To test S...

Serine residues 110 and 114 are required for agonist binding but not antagonist binding to the melatonin MT(1) receptor.

Biochem. Biophys. Res. Commun. 282(5) , 1229-36, (2001)

Site-directed mutation of serine 110 (Ser(3.35)) and serine 114 (Ser(3.39)) in the human melatonin MT(1) receptor to alanine residues reduced ligand binding affinities of seven known melatonin recepto...

[The biosynthesis of low-molecular-weight nitrogen-containing secondary metabolite-alkaloids by the resident strains of Penicillium chrysogenum and Penicillium expansum isolated on the board of the Mir space station ].

Mikrobiologiia 71(6) , 773-7, (2002)

The analysis of the absorption spectra of the low-molecular-weight nitrogen-containing secondary metabolites--alkaloids--of 4 Penicillium chrysogenum strains and 6 Penicillium expansum strains isolate...

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