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柚皮苷

柚皮苷用途

Naringin是黄烷酮糖苷,有很多药理作用,例如抗氧化活性,降血脂,抗癌,抑制细胞色素P450酶。target: p450, IC50: 9026 uM

柚皮苷名称

[ CAS 号 ]:
10236-47-2

[ 中文名 ]:
川陈皮素

[ 英文名 ]:
Naringin

[中文别名 ]:

[英文别名 ]:

2,6-Dimethylpyrimidin-4(1H)-one
2,6-Dimethylpyrimidin-4-ol
Naringenin 7-neohesperidoside
MFCD00148888
2,6-Dimethyl-4(1H)-pyrimidinone
T6N CNJ B1 DQ F1
T6VM DNJ C1 E1
EINECS 233-566-4
2,6-Dimethyl-4(3H)-pyrimidinone
Naringenin 7-Rhamnoglucoside Hydrate

柚皮苷生物活性

[ 描述 ]:

Naringin是黄烷酮糖苷,有很多药理作用,例如抗氧化活性,降血脂,抗癌,抑制细胞色素P450酶。target: p450, IC50: 9026 uM

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450

信号通路 >> 自噬 >> 自噬

天然产物 >> 黄酮类化合物

研究领域 >> 炎症/免疫

[体外研究]

柚皮苷抑制NF-κB信号通路激活。柚皮素抑制HBZY-1细胞中高葡萄糖诱导的增殖,炎症反应和氧化应激损伤[1]。柚皮苷以剂量和时间依赖性方式抑制AGS癌细胞增殖。在Naringin处理的AGS细胞中,PI3K及其活化的下游靶标p-Akt和p-mTOR的磷酸化在2mM处显着降低。柚皮苷在AGS细胞中诱导自噬细胞死亡。柚皮苷激活AGS细胞中的自噬相关蛋白[2]。柚皮苷保护PC12细胞免受3-NP神经毒性。在3-NP诱导的PC12细胞中柚皮苷处理后乳酸脱氢酶释放减少。柚皮苷处理通过增加酶抗氧化剂的活性和还原型谷胱甘肽的水平来增强抗氧化防御[3]。

[体内研究]

柚皮苷治疗显着减轻糖尿病大鼠肾损伤,显着增加糖尿病大鼠体重。柚皮苷的给药有效地减轻了糖尿病大鼠的胶原沉积和肾间质纤维化。柚皮苷治疗可导致ROS和MDA水平降低,SOD和GSH-Px活性增加[1]。柚皮苷的口服给药显着提高了学习和记忆能力。柚皮苷显着增强胰岛素信号通路[3]。

[细胞实验]

将HBZY-1细胞接种到96孔板中，并用各种浓度（1,5,10,25,50,100μM）的柚皮苷预处理2小时。然后用30mM葡萄糖处理细胞24小时。对照组加入相同体积的无菌生理盐水。处理后，将所有孔与20μL5mg/ ml MTT在37℃温育4小时。随后，在去除上清液后，使用100μLDMSO溶解形成的甲crystals晶体。结果在酶标仪上以490nm记录[1]。

[动物实验]

大鼠：将大鼠随机分为6组：对照组，柚皮苷（80 mg / kg），STZ，STZ +柚皮苷（20 mg / kg），STZ +柚皮苷（40 mg / kg），STZ +柚皮苷（80 mg /公斤）。 STZ和STZ +柚皮苷组大鼠腹腔注射STZ（65mg / kg）。对照组和柚皮苷组腹膜内注射相同体积的0.1M柠檬酸盐缓冲液。注射STZ 3天和5天后，通过尾静脉穿刺血液采样测量血糖水平[1]。小鼠：将60只4周龄雄性小鼠随机分成4组，用对照饮食或高脂饮食饲料喂养20周。每天给小鼠服用100mg / kg的柚皮苷。每周测量小鼠体重和食物摄入量。在行为评估之后，用异氟烷深度麻醉动物并在禁食至少5小时后通过断头处死。收集他们的血浆用于进一步分析[4]。

[参考文献]

[1]. Chen F, et al. Naringin Alleviates Diabetic Kidney Disease through Inhibiting Oxidative Stress and Inflammatory Reaction. PLoS One. 2015 Nov 30;10(11):e0143868.

[2]. Raha S, et al. Naringin induces autophagy-mediated growth inhibition by downregulating the PI3K/Akt/mTOR cascade via activation of MAPK pathways in AGS cancer cells. Int J Oncol. 2015 Sep;47(3):1061-9.

[3]. Kulasekaran G, et al. Neuroprotective efficacy of naringin on 3-nitropropionic acid-induced mitochondrial dysfunction through the modulation of Nrf2 signaling pathway in PC12 cells. Mol Cell Biochem. 2015 Nov;409(1-2):199-211.

[4]. Wang D, et al. Naringin Improves Neuronal Insulin Signaling, Brain Mitochondrial Function, and Cognitive Function in High-Fat Diet-Induced Obese Mice. Cell Mol Neurobiol. 2015 Oct;35(7):1061-71.

[相关活性小分子]

柚皮苷物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
928.1±65.0 °C at 760 mmHg

[ 熔点 ]:
166 °C

[ 分子式 ]:
C₂₇H₃₂O₁₄

[ 分子量 ]:
580.53

[ 闪点 ]:
308.5±27.8 °C

[ PSA ]:
225.06000

[ LogP ]:
-0.18

[ 外观性状 ]:
米色至淡黄色粉末

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.564

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (吸湿)

[ 水溶解性 ]:
可溶于：醇,丙酮；极微溶：乙醚

柚皮苷MSDS

详细MSDS(安全技术说明书)

柚皮苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QN6340000

CHEMICAL NAME :: Naringin

CAS REGISTRY NUMBER :: 10236-47-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C27-H32-O14

MOLECULAR WEIGHT :: 580.59

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EKMMA8 Eksperimentalna Meditsina i Morfologiya. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.1- 1962- Volume(issue)/page/year: 19,207,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EKMMA8 Eksperimentalna Meditsina i Morfologiya. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.1- 1962- Volume(issue)/page/year: 19,207,1980

柚皮苷安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
QN6340000

柚皮苷上下游产品

柚皮苷上游产品

柚皮苷下游产品

柚皮苷制备

由葡萄柚（Citrus paradisl）、夏柑、柚等柑橘类果皮抽提物加工而得。

柚皮苷文献

Preconditioning L6 Muscle Cells with Naringin Ameliorates Oxidative Stress and Increases Glucose Uptake.

PLoS ONE 10 , e0132429, (2015)

Enhanced oxidative stress contributes to pathological changes in diabetes and its complications. Thus, strategies to reduce oxidative stress may alleviate these pathogenic processes. Herein, we have i...

Pseudomonas aeruginosa Biofilm Formation and Persistence, along with the Production of Quorum Sensing-Dependent Virulence Factors, Are Disrupted by a Triterpenoid Coumarate Ester Isolated from Dalbergia trichocarpa, a Tropical Legume.

PLoS ONE 10 , e0132791, (2015)

Recently, extracts of Dalbergia trichocarpa bark have been shown to disrupt P. aeruginosa PAO1 quorum sensing (QS) mechanisms, which are key regulators of virulence factor expression and implicated in...

The antioxidant and antigenotoxic properties of citrus phenolics limonene and naringin.

Food Chem. Toxicol. 81 , 160-70, (2015)

Phenolic compounds not only contribute to the sensory qualities of fruits and vegetables but also exhibit several health protective properties. Limonene and naringin are the most popular phenolics fou...

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柚皮苷