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N-甲基靛红酸酐

N-甲基靛红酸酐用途

N-Methylisatoic anhydride (NMIA) 是 RNA 的 2'-OH 选择性酰化剂,广泛用于使用 SHAPE(通过引物延伸分析的选择性2'-OH 酰化)技术解析二级 RNA 结构。

N-甲基靛红酸酐名称

[ CAS 号 ]:
10328-92-4

[ 中文名 ]:
1-甲基苯唑

[ 英文名 ]:
N-Methylisatoic Anhydride

[中文别名 ]:

N-甲基靛红酸酐

[英文别名 ]:

1-Methyl-1H-benzo[d][1,3]oxazine-2,4-dione
N-Methylisatoic Anhydride
MFCD00006815
1-methyl-3,1-benzoxazine-2,4-dione
EINECS 233-714-8

N-甲基靛红酸酐生物活性

[ 描述 ]:

N-Methylisatoic anhydride (NMIA) 是 RNA 的 2'-OH 选择性酰化剂,广泛用于使用 SHAPE(通过引物延伸分析的选择性2'-OH 酰化)技术解析二级 RNA 结构。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Ursuegui S, et al. Biotin-conjugated N-methylisatoic anhydride: a chemical tool for nucleic acid separation by selective 2'-hydroxyl acylation of RNA. Chem Commun (Camb). 2014 Jun 1;50(43):5748-51.

N-甲基靛红酸酐物理化学性质

[ 密度 ]:
1.348 g/cm3

[ 沸点 ]:
297.5ºC at 760 mmHg

[ 熔点 ]:
165 °C (dec.)(lit.)

[ 分子式 ]:
C₉H₇NO₃

[ 分子量 ]:
177.15700

[ 闪点 ]:
133.7ºC

[ 精确质量 ]:
177.04300

[ PSA ]:
52.21000

[ LogP ]:
0.49170

[ 外观性状 ]:
褐色大块

[ 蒸汽密度 ]:
6.1 (vs air)

[ 蒸汽压 ]:
0.00135mmHg at 25°C

[ 折射率 ]:
1.583

[ 储存条件 ]:
-20°C

N-甲基靛红酸酐MSDS

N-甲基靛红酸酐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DM3140000

CHEMICAL NAME :: 2H-3,1-Benzoxazine-2,4(1H)-dione, 1-methyl-

CAS REGISTRY NUMBER :: 10328-92-4

BEILSTEIN REFERENCE NO. :: 0383957

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H7-N-O3

MOLECULAR WEIGHT :: 177.17

WISWESSER LINE NOTATION :: T66 BNVOVJ B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 34800 mg/kg

SEX/DURATION :: male 8 day(s) pre-mating female 21 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN. Volume(issue)/page/year: 15,7,1966

N-甲基靛红酸酐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DM3140000

[ 海关编码 ]:
2934999090

N-甲基靛红酸酐合成路线

N-甲基靛红酸酐上下游产品

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N-甲基靛红酸酐海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

N-甲基靛红酸酐文献

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Telomerase is a ribonucleoprotein (RNP) enzyme that requires an integral telomerase RNA (TR) subunit, in addition to the catalytic telomerase reverse transcriptase (TERT), for enzymatic function. The ...

Simultaneous determination of myo-inositol and scyllo-inositol by MEKC as a rapid monitoring tool for inositol levels.

Electrophoresis 28(8) , 1221-8, (2007)

A simple and rapid MEKC method was developed for the simultaneous determination of myo-inositol, scyllo-inositol, and glucose. Prior to electrophoretic separation, the nonfluorescent inositols and glu...

Role of lysine binding residues in the global folding of the lysC riboswitch.

RNA Biol. 12 , 1372-82, (2016)

Riboswitches regulate gene expression by rearranging their structure upon metabolite binding. The lysine-sensing lysC riboswitch is a rare example of an RNA aptamer organized around a 5-way helical ju...

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