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肉桂醇； beta-苯丙烯醇

肉桂醇； beta-苯丙烯醇用途

Cinnamyl Alcohol 从板栗花中分离得到的活性成分,抑制增加的 PPARγ 的表达,具有抗肥胖的作用。

肉桂醇； beta-苯丙烯醇名称

[ CAS 号 ]:
104-54-1

[ 中文名 ]:
肉桂醇

[ 英文名 ]:
Cinnamyl alcohol

[英文别名 ]:

cinnamic alcohol
stylone
trans-3-phenyl-2-propen-1-ol
Peruvin
Ciamyl alcohol
STYRYL CARBINOL
Cinnamylalkohol
(E)-cinnamyl alcohol
(E)-3-phenylprop-2-en-1-ol
3-PHENYLALLYLOL

肉桂醇； beta-苯丙烯醇生物活性

[ 描述 ]:

Cinnamyl Alcohol 从板栗花中分离得到的活性成分,抑制增加的 PPARγ 的表达,具有抗肥胖的作用。

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> PPAR

研究领域 >> 代谢疾病

[参考文献]

[1]. Hwang DI, et al. Cinnamyl Alcohol, the Bioactive Component of Chestnut Flower Absolute, Inhibits Adipocyte Differentiation in 3T3-L1 Cells by Downregulating Adipogenic Transcription Factors. Am J Chin Med. 2017;45(4):833-846.

肉桂醇； beta-苯丙烯醇物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
250.0±0.0 °C at 760 mmHg

[ 熔点 ]:
30-33 °C(lit.)

[ 分子式 ]:
C₉H₁₀O

[ 分子量 ]:
134.175

[ 闪点 ]:
124.8±14.5 °C

[ 精确质量 ]:
134.073166

[ PSA ]:
20.23000

[ LogP ]:
1.70

[ 外观性状 ]:
无色固体

[ 蒸汽密度 ]:
4.6 (vs air)

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.599

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
1.8 g/L (20 ºC)

肉桂醇； beta-苯丙烯醇MSDS

肉桂醇； beta-苯丙烯醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GE2200000

CHEMICAL NAME :: Cinnamyl alcohol

CAS REGISTRY NUMBER :: 104-54-1

BEILSTEIN REFERENCE NO. :: 1903999

LAST UPDATED :: 199701

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C9-H10-O

MOLECULAR WEIGHT :: 134.19

WISWESSER LINE NOTATION :: Q2U1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2675 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2675 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6366 mg/kg/17W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes

MUTATION DATA

TYPE OF TEST :: DNA repair

TEST SYSTEM :: Bacteria - Bacillus subtilis

DOSE/DURATION :: 10 mg/disc

REFERENCE :: OIGZDE Osaka-shi Igakkai Zasshi. Journal of Osaka City Medical Association. (Osaka-shi Igakkai, c/o Osaka-shiritsu Daigaku Igakubu, 1-4-54 Asahi-cho, Abeno-ku, Osaka, 545, Japan) V.24- 1975- Volume(issue)/page/year: 34,267,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83181 No. of Facilities: 163 (estimated) No. of Industries: 6 No. of Occupations: 36 No. of Employees: 8942 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83181 No. of Facilities: 4817 (estimated) No. of Industries: 25 No. of Occupations: 48 No. of Employees: 76974 (estimated) No. of Female Employees: 43896 (estimated)

肉桂醇； beta-苯丙烯醇安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H317-H319

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36;R43

[ 安全声明 (欧洲) ]:
S26-S36/37-S37/39-S24

[ 危险品运输编码 ]:
2811

[ WGK德国 ]:
2

[ RTECS号 ]:
GE2200000

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2912299000

肉桂醇； beta-苯丙烯醇合成路线

肉桂醇； beta-苯丙烯醇上下游产品

肉桂醇； beta-苯丙烯醇上游产品

肉桂醇； beta-苯丙烯醇下游产品

肉桂醇； beta-苯丙烯醇制备

1.桂醛还原法
在1份质量的苄醇中加入0.01份铝屑，加热至60℃反应放出氢气，温度升高至180℃，至停止放出氢气为止。苄醇铝溶液经冷却、过滤后加入到苄醇和桂醛的混合物(质量1：1)中。在0.0027MPa的条件下加热至沸，在80℃和回流比3～4下蒸出反应生成的苯甲醛，同时补加苄醇。直到蒸出理论量95%的苯甲醛后停止加料，并蒸出剩余的苄醇，然后蒸出肉桂醇粗品。再经减压精馏，收集117℃(7kPa)馏分，即为产品。
苏合香脂皂化法
桂醇以桂酸桂酯的形式天然存在于秘鲁香脂、安息香脂和苏合香脂中。将苏合香脂在10%的氢氧化钠溶液中加热皂化5h，再用乙醚萃取出水解产物桂醇，最后经减压蒸馏提纯而得成品。

2.将苏合香脂在氢氧化钠溶液中加热皂化，经萃取、减压蒸馏制得。或者用异丙烯基铝、丁醇铝或苄醇铝还原桂醛制得。

3. 烟草：BU，14。

肉桂醇； beta-苯丙烯醇海关

[ 海关编码 ]: 2912299000

[ 中文概述 ]:
2912299000. 其他不含其他含氧基的环醛. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 四聚甲醛报明外观

[ Summary ]:
2912299000. other cyclic aldehydes without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

肉桂醇； beta-苯丙烯醇文献

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Bioorg. Med. Chem. 19 , 2392-6, (2011)

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