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盐酸普拉克索

盐酸普拉克索用途

Pramipexole双盐酸盐是部分和完全的D2S,D2L,D3和D4受体激动剂, Ki分别为3.9,2.2,0.5和5.1 nM。

盐酸普拉克索名称

[ CAS 号 ]:
104632-25-9

[ 中文名 ]:
盐酸普拉克索

[ 英文名 ]:
Pramipexole dihydrochloride

[中文别名 ]:

(S)-普拉克索二盐酸化物

[英文别名 ]:

Pramipexole hydrochloride
Pramipexole dihydrochloride
MFCD00876894
(S)-Pramipexole Dihydrochloride
Pramipexole (dihydrochloride)

盐酸普拉克索生物活性

[ 描述 ]:

Pramipexole双盐酸盐是部分和完全的D2S,D2L,D3和D4受体激动剂, Ki分别为3.9,2.2,0.5和5.1 nM。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体

信号通路 >> 神经信号通路 >> 多巴胺受体

研究领域 >> 神经疾病

[参考文献]

[1]. Mierau J, Schneider FJ, Ensinger HA et al. Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors. Eur J Pharmacol. 1995 Jun 23;290(1):29-36.

[2]. El-Mallakh RS, Penagaluri P, Kantamneni A et al. Long-term use of pramipexole in bipolar depression: a naturalistic retrospective chart review. Psychiatr Q. 2010 Sep;81(3):207-13.

[3]. Perez-Lloret S, Rey MV, Ratti L, Rascol O. Pramipexole for the treatment of early Parkinson's disease. Expert Rev Neurother. 2011 Jul;11(7):925-35.

[4]. Hametner EM, Seppi K, Poewe W. Pramipexole extended release in Parkinson's disease. Expert Rev Neurother. 2011 Sep;11(9):1229-34.

[5]. Hametner EM, Seppi K, Poewe W. Role and clinical utility of pramipexole extended release in the treatment of early Parkinson's disease. Clin Interv Aging. 2012;7:83-8.

[相关活性小分子]

盐酸普拉克索物理化学性质

[ 沸点 ]:
378ºC at 760 mmHg

[ 熔点 ]:
288-290ºC

[ 分子式 ]:
C₁₀H₁₉Cl₂N₃S

[ 分子量 ]:
284.249

[ 闪点 ]:
182.4ºC

[ 精确质量 ]:
283.067688

[ PSA ]:
79.18000

[ LogP ]:
4.15830

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
6.49E-06mmHg at 25°C

[ 储存条件 ]:
Desiccate at RT

盐酸普拉克索安全信息

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2934999090

盐酸普拉克索合成路线

详细合成路线

盐酸普拉克索上下游产品

盐酸普拉克索上游产品

盐酸普拉克索下游产品

盐酸普拉克索海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

盐酸普拉克索文献

Pramipexole reduces parkinsonian tremor induced by pilocarpine infusion in the rat striatum.

Pharmacol. Biochem. Behav. 131 , 1-5, (2015)

Pramipexole is widely prescribed for the treatment of Parkinson's disease. This dopamine (DA) receptor agonist has a higher affinity for D3 over D2 receptors. We compared the effect of pramipexole to ...

Alterations of BDNF and trkB mRNA expression in the 6-hydroxydopamine-induced model of preclinical stages of Parkinson's disease: an influence of chronic pramipexole in rats.

PLoS ONE 10(3) , e0117698, (2015)

Our recent study has indicated that a moderate lesion of the mesostriatal and mesolimbic pathways in rats, modelling preclinical stages of Parkinson's disease, induces a depressive-like behaviour whic...

De novo expression of dopamine D2 receptors on microglia after stroke.

J. Cereb. Blood Flow Metab. 35 , 1804-11, (2015)

Dopamine is the predominant catecholamine in the brain and functions as a neurotransmitter. Dopamine is also a potent immune modulator. In this study, we have characterized the expression of dopamine ...

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